Objective A major clinical problem in Orthopaedics is the repair of traumatic articular
cartilage lesions. The MRL/MpJ strain of mice has the remarkable ability to regenerate ear
hole punch wounds seamlessly including the scarless replacement of multiple tissues. The …

To evaluate the ability of MR T2 mapping (8.5 T) to characterize ex vivo longitudinally,
morphologically and quantitatively, alginate-based tissue engineering in a rat model of
patellar cartilage chondral focal defect. Calibrated rat patellar cartilage defects (1.3 mm) …

Objective: to evaluate the ability of T2 mapping on an 8.5 T imager to characterize
morphologically and quantitatively spontaneous repair of rat patellar cartilage following full
thickness defect. Methods: Patellar cartilage defects were created in 24 rats knees on D0 …

Osteoarthritis is influenced by genetic and environment factors, including mechanical stress;
however, the relationship between running and the development of osteoarthritis remains a
matter of controversy. We investigated whether osteoarthritic change could be obtained in a …

Background. Supplemented postoperative activity was compared to standard activity for
effects on wound healing, subcutaneous tissue perfusion, and oxygen (PscO 2) following hip
replacement (THR). Methods. 58 patients were randomized to standard post-THR activity …

Study Design. Using a running rat model, the effects of physical exercise on cellular function
and intervertebral disc (IVD) extracellular matrix were studied. Objective. To investigate
whether 3-weeks treadmill running exercise can stimulate matrix production and cellular …

The regeneration of hyaline cartilage remains clinically challenging. Here, we evaluated the
therapeutic effects of using cell-free porous poly (lactic-co-glycolic acid)(PLGA) graft
implants (PGIs) along with early loading exercise to repair a full-thickness osteochondral …

Background A periosteal flap is frequently used in procedures involving repair of articular
cartilage defects. Hypertrophy of the repair tissue, probably from a retained periosteum, is a
clinical problem but not much is known about this issue. The objective of the present …

Background Mechanical stimulation has a great influence on articular cartilage
regeneration. The objective of this study was to clarify the temporal sequences of
spontaneous repair of weightless or immobilized joints. Methods An osteochondral defect …

Objective Current medical practice for the treatment of articular cartilage lesions remains a
clinical challenge due to the limited self-repair ability of articular cartilage. Both experimental
and clinical researches show that moderate exercise can improve articular cartilage repair …