Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this
are multifactorial, although maintaining a growth permissive environment in the distal nerve
stump following repair is arguably the most important. The optimal environment for axonal …

Polyvinyl alcohol hydrogel (PVA) is a synthetic polymer with an increasing application in the
biomedical field that can potentially be used for vascular grafting. However, the tissue and
blood–material interactions of such gels and membranes are unknown in detail. The …

The structure and function of peripheral nerves can be affected by a range of conditions with
severe consequences in these patients. Currently, there are several surgical techniques
available to treat peripheral nerve defects. Direct repair is the preferred treatment for short …

Human Wharton's jelly (WJ) has become a preferred source of mesenchymal stem cells
(MSCs) whose clinical applications are limited by the use of adequate xeno-free (XF), in vitro
manipulation conditions. Therefore, the objective of our study was to characterize WJ …

Mesenchymal stem cell (MSC) therapy has attracted the attention of scientists and clinicians
around the world. Basic and pre-clinical experimental studies have highlighted the positive
effects of MSC treatment after spinal cord and peripheral nerve injury. These effects are …

Human mesenchymal stem cells (hMSCs) from umbilical cord (UC) blood (UCB) and matrix
are tested clinically for a variety of pathologies but in vitro expansion using culture media
containing fetal bovine serum (FBS) is essential to achieve appropriate cell numbers for …

Peripheral nerve injury can have a potentially devastating impact on a patient's quality of life,
resulting in severe disability with substantial social and personal cost. Refined microsurgical
techniques, advances in peripheral nerve topography, and a better understanding of the …

The healing process of the skin is a dynamic procedure mediated through a complex
feedback of growth factors secreted by a variety of cells types. Despite the most recent
advances in wound healing management and surgical procedures, these techniques still fail …

Artificial nanofiber nerve guides have gained huge interest in bridging nerve gaps and
associated peripheral nerve regeneration due to its high surface area, flexibility and porous
structure. In this study, electrospun poly (ε‐caprolactone)/gelatin (PCL/Gel) nanofibrous mats …

In peripheral nerves MSCs can modulate Wallerian degeneration and the overall
regenerative response by acting through paracrine mechanisms directly on regenerating
axons or upon the nerve-supporting Schwann cells. In the present study, the effect of human …