Various types of grafts have been traditionally used to restore damaged bones. In the late
1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their
biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In …

Various types of grafts have been traditionally used to restore damaged bones. In the late
1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their
biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In …

Calcium phosphate materials have been used increasingly in the past 40 years as bone
graft substitutes in the dental and orthopedic fields. Accordingly, numerous fabrication
methods have been proposed and used. However, the controlled production of spherical …

The history of calcium phosphates in the medicine field starts in 1769 when the first
evidence of its existence in the bone tissue is discovered. Since then, the interest for calcium
phosphates has increased among the scientific community. Their study has been developed …

Background. This work compares the osteoblastic behaviour of a bone marrow (BM)
aspirate and a prepared BM concentrate of nucleated cells associated with a glass
reinforced hydroxyapatite composite (GRHC) in a microporous pellet formulation. Methods …

In the last decades, the well‐known disadvantages of autografts and allografts have driven
to the development of synthetic bone grafts for bone regeneration. Bonelike®, a glass‐
reinforced hydroxyapatite (HA) composite was developed and registered for bone grafting …

Although bioactive glasses are successfully used as bone substitutes, recent studies have
revealed that the high alkali content in these glasses leads to fast in vivo degradation rates
that may not match the rate of new bone ingrowth. This prompted us to design and develop …

Introduction. Intertrochanteric hip fractures occur in the proximal femur. They are very
common in the elderly and are responsible for high rates of morbidity and mortality. The
authors hypothesized that adding an autologous bone marrow stem cells concentrate …

Increasing relevance has been attributed to hydrogels due to their ability to provide an
extracellular matrix (ECM)-like environment for cellular adhesion and proliferation, acting as
mechanical scaffolds for tissue remodeling or as delivery matrices. In vivo biocompatibility of …

Presently, several bone graft substitutes are being developed or already available for
clinical use. However, the limited number of clinical and in vivo trials for direct comparison
between these products may complicate this choice. One of the main reasons for this …