Articular cartilage injury and degeneration are leading causes of disability. Animal studies
are critically important to developing effective treatments for cartilage injuries. This review
focuses on the use of animal models for the study of the repair and regeneration of focal …

Objective Review the literature for single site cartilage defect research and evaluate the
respective strengths and weaknesses of different preclinical animal models. Method A
literature search for animal models evaluating single site cartilage defects was performed …

Periodontitis is considered to be caused by bacterial biofilms (dental plaque), and its onset
and progress are modulated by a variety of risk factors, such as systemic conditions and
smoking. Some success has been achieved in suppressing the progress of periodontitis by …

Study Design. Skeletal tissues of mice with an inactivated allele of the Col2a1 gene for Type
II collagen (“heterozygous knockout”) were studied. Objective. To determine whether a
heterozygous inactivation of the Col2a1 gene has a role in the etiology of spine disorders …

Microfracture used to treat articular cartilage injuries can facilitate access to stem cells in the
bone marrow and stimulate cartilage regeneration. However, the regenerated cartilage is
fibrocartilage as opposed to hyaline articular cartilage and is thinner than native cartilage …

Objective The present study aims at evaluating, in a rat model of cartilage defect, the
potential of various polymers as filling and repair biomaterials. The macroscopic and
histological observations are compared to biochemical parameters in order to appreciate the …

Basic fibroblast growth factor (FGF‐2) can enhance biological potentials of periodontal
ligament cells and its topical application induces considerable periodontal tissue
regeneration in vivo. In this study, we examined the effect of FGF‐2 on the production of …

Repair of cartilage damage with autologous chondrocyte transplantation (ACT) has become
popular in clinical use during the past few years. Although clinical results have mostly been
successful, several unanswered questions remain regarding the biological mechanism of …

Abstract Fibroblast growth factor‐2 (FGF‐2) regulates a variety of functions of the periodontal
ligament (PDL) cell, which is a key player during tissue regeneration following periodontal
tissue breakdown by periodontal disease. In this study, we investigated the effects of FGF‐2 …

Osteoarthritis is influenced by genetic and environment factors, including mechanical stress;
however, the relationship between running and the development of osteoarthritis remains a
matter of controversy. We investigated whether osteoarthritic change could be obtained in a …