Abstract The 2014 Nucleic Acids Research Database Issue includes descriptions of 58 new
molecular biology databases and recent updates to 123 databases previously featured in
NAR or other journals. For convenience, the issue is now divided into eight sections that …

Synthetic promoters, especially minimally sized, are critical for advancing fungal synthetic
biology. Fungal promoters often span hundreds of base pairs, nearly ten times the amount of
bacterial counterparts. This size limits large-scale synthetic biology efforts in yeasts. Here we …

Studies of individual living cells have revealed that many transcription factors activate in
dynamic, and often stochastic, pulses within the same cell. However, it has remained
unclear whether cells might exploit the dynamic interaction of these pulses to control gene …

Abstract The Saccharomyces Genome Database (SGD; http://www. yeastgenome. org) is the
community resource for genomic, gene and protein information about the budding yeast
Saccharomyces cerevisiae, containing a variety of functional information about each yeast …

Fungal secondary metabolite biosynthesis genes are of major interest due to the
pharmacological properties of their products (like mycotoxins and antibiotics). The genome
of the plant pathogenic fungus Fusarium graminearum codes for a large number of …

TOR kinase complex I (TORC1) is a key regulator of cell growth and metabolism in all
eukaryotes. Previous studies in yeast have shown that three GTPases–Gtr1, Gtr2 and Rho1–
bind to TORC1 in nitrogen and amino acid starvation conditions to block phosphorylation of …

Abstract This year's Database Issue of Nucleic Acids Research contains 152 papers that
include descriptions of 54 new databases and update papers on 98 databases, of which 16
have not been previously featured in NAR. As always, these databases cover a broad range …

Transcription networks consist of hundreds of transcription factors with thousands of often
overlapping target genes. While we can reliably measure gene expression changes, we still
understand relatively little why expression changes the way it does. How does a coordinated …

The establishment of a heterologous pathway in a microbial host for the production of
industrially relevant chemicals at high titers and yields requires efficient adjustment of the
central carbon metabolism to ensure that flux is directed toward the product of interest. This …

Biclustering, the discovery of sets of objects with a coherent pattern across a subset of
conditions, is a critical task to study a wide-set of biomedical problems, where molecular
units or patients are meaningfully related with a set of properties. The challenging …