Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative
stress is coupled to the oxidative degradation of lipid membranes, also known as lipid …

To build an energy and material secure future, a next generation of renewable fuels
produced from lignocellulosic biomass is required. Although lignocellulosic biomass, which
represents an abundant, inexpensive and renewable source for bioethanol production, is of …

Background Nearly all processes in living cells are pH dependent, which is why intracellular
pH (pH i) is a tightly regulated physiological parameter in all cellular systems. However, in
microbes such as yeast, pH i responds to extracellular conditions such as the availability of …

The conversion of biomass into ethanol using fast, cheap, and efficient methodologies to
disintegrate and hydrolyse the lignocellulosic biomass is the major challenge of the
production of the second-generation ethanol. This revision describes the most relevant …

Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to
weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a
higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular …

Successful reverse engineering of mutants that have been obtained by nontargeted strain
improvement has long presented a major challenge in yeast biotechnology. This paper
reviews the use of genome-wide approaches for analysis of Saccharomyces cerevisiae …

Beyond its classical biotechnological applications such as food and beverage production or
as a cell factory, the yeast Saccharomyces cerevisiae is a valuable model organism to study
fundamental mechanisms of cell response to stressful environmental changes. Acetic acid is …

Fermentation of lignocellulosic hydrolyzates and other carbon sources to ethanol is affected
by the different substances present in the cultivation media. A high concentration of sugars is
desirable in all ethanol processes, to have a higher concentration of ethanol, thus reducing …

When using microorganisms as cell factories in the production of bio-based fuels or
chemicals from lignocellulosic hydrolysate, inhibitory concentrations of acetic acid, released
from the biomass, reduce the production rate. The undissociated form of acetic acid enters …

The success of food and beverage production processes carried out by Saccharomyces
cerevisiae and the thriving of food spoilage fungi are dependent on the ability of a cell to
cope with the many environmental insults imposed during food production and preservation …