Diana Machado
Diana Machado
Laboratório de Micobacterias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina
Email confirmado em ihmt.unl.pt - Página inicial
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Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis
D Machado, I Couto, J Perdigão, L Rodrigues, I Portugal, P Baptista, ...
PloS one 7 (4), e34538, 2012
2372012
Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex
L Rodrigues, D Machado, I Couto, L Amaral, M Viveiros
Infection, Genetics and Evolution 12 (4), 695-700, 2012
1422012
High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations
D Machado, J Perdigao, J Ramos, I Couto, I Portugal, C Ritter, ...
Journal of Antimicrobial Chemotherapy 68 (8), 1728-1732, 2013
1172013
Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs
M Viveiros, M Martins, L Rodrigues, D Machado, I Couto, J Ainsa, ...
Expert review of anti-infective therapy 10 (9), 983-998, 2012
1072012
Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus
SS Costa, C Falcão, M Viveiros, D Machado, M Martins, J Melo-Cristino, ...
BMC microbiology 11 (1), 1-12, 2011
1032011
Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study
E Cambau, M Viveiros, D Machado, L Raskine, C Ritter, E Tortoli, ...
Journal of Antimicrobial Chemotherapy 70 (3), 686-696, 2015
982015
Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis
B Veigas, D Machado, J Perdigao, I Portugal, I Couto, M Viveiros, ...
Nanotechnology 21 (41), 415101, 2010
892010
Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil
T Coelho, D Machado, I Couto, R Maschmann, D Ramos, A von Groll, ...
Frontiers in microbiology 6, 330, 2015
722015
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs
JE Phelan, DM O’Sullivan, D Machado, J Ramos, YEA Oppong, ...
Genome medicine 11 (1), 1-7, 2019
712019
Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis
D Machado, D Pires, J Perdigão, I Couto, I Portugal, M Martins, L Amaral, ...
PloS one 11 (2), e0149326, 2016
692016
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting
J Perdigão, H Silva, D Machado, R Macedo, F Maltez, C Silva, L Jordao, ...
BMC genomics 15 (1), 1-20, 2014
662014
The role of efflux pumps in macrolide resistance in Mycobacterium avium complex
L Rodrigues, D Sampaio, I Couto, D Machado, WV Kern, L Amaral, ...
International journal of antimicrobial agents 34 (6), 529-533, 2009
662009
Interplay between mutations and efflux in drug resistant clinical isolates of Mycobacterium tuberculosis
D Machado, TS Coelho, J Perdigão, C Pereira, I Couto, I Portugal, ...
Frontiers in microbiology 8, 711, 2017
562017
Rational design and synthesis of thioridazine analogues as enhancers of the antituberculosis therapy
M Pieroni, D Machado, E Azzali, S Santos Costa, I Couto, G Costantino, ...
Journal of medicinal chemistry 58 (15), 5842-5853, 2015
522015
Challenging the drug-likeness dogma for new drug discovery in tuberculosis
D Machado, M Girardini, M Viveiros, M Pieroni
Frontiers in microbiology 9, 1367, 2018
502018
Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery
E Azzali, D Machado, A Kaushik, F Vacondio, S Flisi, CS Cabassi, ...
Journal of medicinal chemistry 60 (16), 7108-7122, 2017
472017
HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality
AM Tavares, I Fronteira, I Couto, D Machado, M Viveiros, AB Abecasis, ...
PloS one 12 (9), e0185526, 2017
442017
The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs
J Phelan, DM O’Sullivan, D Machado, J Ramos, AS Whale, J O’Grady, ...
Genome medicine 8 (1), 1-9, 2016
412016
Identification of nontuberculous mycobacteria in clinical samples using molecular methods: a 3‐year study
I Couto, D Machado, M Viveiros, L Rodrigues, L Amaral
Clinical Microbiology and Infection 16 (8), 1161-1164, 2010
402010
Contribution of efflux to colistin heteroresistance in a multidrug resistant Acinetobacter baumannii clinical isolate
D Machado, J Antunes, A Simões, J Perdigão, I Couto, M McCusker, ...
Journal of medical microbiology 67 (6), 740-749, 2018
312018
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