|Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis|
D Machado, I Couto, J Perdigao, L Rodrigues, I Portugal, P Baptista, ...
PloS one 7 (4), e34538, 2012
|Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex|
L Rodrigues, D Machado, I Couto, L Amaral, M Viveiros
Infection, Genetics and Evolution 12 (4), 695-700, 2012
|High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations|
D Machado, J Perdigao, J Ramos, I Couto, I Portugal, C Ritter, ...
Journal of Antimicrobial Chemotherapy 68 (8), 1728-1732, 2013
|Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus|
SS Costa, C Falcão, M Viveiros, D Machado, M Martins, J Melo-Cristino, ...
BMC microbiology 11 (1), 241, 2011
|Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs|
M Viveiros, M Martins, L Rodrigues, D Machado, I Couto, J Ainsa, ...
Expert review of anti-infective therapy 10 (9), 983-998, 2012
|Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study|
E Cambau, M Viveiros, D Machado, L Raskine, C Ritter, E Tortoli, ...
Journal of Antimicrobial Chemotherapy 70 (3), 686-696, 2015
|Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis|
B Veigas, D Machado, J Perdigao, I Portugal, I Couto, M Viveiros, ...
Nanotechnology 21 (41), 415101, 2010
|The role of efflux pumps in macrolide resistance in Mycobacterium avium complex|
L Rodrigues, D Sampaio, I Couto, D Machado, WV Kern, L Amaral, ...
International journal of antimicrobial agents 34 (6), 529-533, 2009
|Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil|
T Coelho, D Machado, I Couto, R Maschmann, D Ramos, A von Groll, ...
Frontiers in microbiology 6, 330, 2015
|Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting|
J Perdigão, H Silva, D Machado, R Macedo, F Maltez, C Silva, L Jordao, ...
BMC genomics 15 (1), 991, 2014
|Rational design and synthesis of thioridazine analogues as enhancers of the antituberculosis therapy|
M Pieroni, D Machado, E Azzali, S Santos Costa, I Couto, G Costantino, ...
Journal of medicinal chemistry 58 (15), 5842-5853, 2015
|Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis|
D Machado, D Pires, J Perdigão, I Couto, I Portugal, M Martins, L Amaral, ...
PloS one 11 (2), e0149326, 2016
|Identification of nontuberculous mycobacteria in clinical samples using molecular methods: a 3‐year study|
I Couto, D Machado, M Viveiros, L Rodrigues, L Amaral
Clinical microbiology and infection 16 (8), 1161-1164, 2010
|Interplay between mutations and efflux in drug resistant clinical isolates of Mycobacterium tuberculosis|
D Machado, TS Coelho, J Perdigão, C Pereira, I Couto, I Portugal, ...
Frontiers in microbiology 8, 711, 2017
|Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery|
E Azzali, D Machado, A Kaushik, F Vacondio, S Flisi, CS Cabassi, ...
Journal of Medicinal Chemistry 60 (16), 7108-7122, 2017
|From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: the stepwise mode of resistance acquisition|
J Perdigão, R Macedo, C Silva, D Machado, I Couto, M Viveiros, L Jordao, ...
Journal of Antimicrobial Chemotherapy 68 (1), 27-33, 2013
|HIV and tuberculosis co-infection among migrants in Europe: A systematic review on the prevalence, incidence and mortality|
AM Tavares, I Fronteira, I Couto, D Machado, M Viveiros, AB Abecasis, ...
PloS one 12 (9), e0185526, 2017
|The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs|
J Phelan, DM O’Sullivan, D Machado, J Ramos, AS Whale, J O’Grady, ...
Genome medicine 8 (1), 132, 2016
|Challenging the drug-likeness dogma for new drug discovery in tuberculosis|
D Machado, M Girardini, M Viveiros, M Pieroni
Frontiers in microbiology 9, 1367, 2018
|Direct detection by the Xpert MTB/RIF assay and characterization of multi and poly drug-resistant tuberculosis in Guinea-Bissau, West Africa|
P Rabna, J Ramos, G Ponce, L Sanca, M Mané, A Armada, D Machado, ...
PLoS One 10 (5), e0127536, 2015