|Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis|
D Machado, I Couto, J Perdigão, L Rodrigues, I Portugal, P Baptista, ...
PloS one 7 (4), e34538, 2012
|Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex|
L Rodrigues, D Machado, I Couto, L Amaral, M Viveiros
Infection, Genetics and Evolution 12 (4), 695-700, 2012
|High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations|
D Machado, J Perdigao, J Ramos, I Couto, I Portugal, C Ritter, ...
Journal of Antimicrobial Chemotherapy 68 (8), 1728-1732, 2013
|Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs|
M Viveiros, M Martins, L Rodrigues, D Machado, I Couto, J Ainsa, ...
Expert review of anti-infective therapy 10 (9), 983-998, 2012
|Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus|
SS Costa, C Falcão, M Viveiros, D Machado, M Martins, J Melo-Cristino, ...
BMC microbiology 11 (1), 241, 2011
|Au-nanoprobes for detection of SNPs associated with antibiotic resistance in Mycobacterium tuberculosis|
B Veigas, D Machado, J Perdigao, I Portugal, I Couto, M Viveiros, ...
Nanotechnology 21 (41), 415101, 2010
|Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study|
E Cambau, M Viveiros, D Machado, L Raskine, C Ritter, E Tortoli, ...
Journal of Antimicrobial Chemotherapy 70 (3), 686-696, 2014
|Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil|
T Coelho, D Machado, I Couto, R Maschmann, D Ramos, A von Groll, ...
Frontiers in microbiology 6, 330, 2015
|The role of efflux pumps in macrolide resistance in Mycobacterium avium complex|
L Rodrigues, D Sampaio, I Couto, D Machado, WV Kern, L Amaral, ...
International journal of antimicrobial agents 34 (6), 529-533, 2009
|Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting|
J Perdigão, H Silva, D Machado, R Macedo, F Maltez, C Silva, L Jordao, ...
BMC genomics 15 (1), 991, 2014
|Rational design and synthesis of thioridazine analogues as enhancers of the antituberculosis therapy|
M Pieroni, D Machado, E Azzali, S Santos Costa, I Couto, G Costantino, ...
Journal of medicinal chemistry 58 (15), 5842-5853, 2015
|Identification of nontuberculous mycobacteria in clinical samples using molecular methods: a 3‐year study|
I Couto, D Machado, M Viveiros, L Rodrigues, L Amaral
Clinical Microbiology and Infection 16 (8), 1161-1164, 2010
|Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant Mycobacterium tuberculosis|
D Machado, D Pires, J Perdigão, I Couto, I Portugal, M Martins, L Amaral, ...
PloS one 11 (2), e0149326, 2016
|From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: the stepwise mode of resistance acquisition|
J Perdigão, R Macedo, C Silva, D Machado, I Couto, M Viveiros, L Jordao, ...
Journal of Antimicrobial Chemotherapy 68 (1), 27-33, 2012
|The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs|
J Phelan, DM O’Sullivan, D Machado, J Ramos, AS Whale, J O’Grady, ...
Genome medicine 8 (1), 132, 2016
|Interplay between mutations and efflux in drug resistant clinical isolates of Mycobacterium tuberculosis|
D Machado, TS Coelho, J Perdigão, C Pereira, I Couto, I Portugal, ...
Frontiers in microbiology 8, 711, 2017
|Molecular tools for rapid identification and novel effective therapy against MDRTB/XDRTB infections|
M Viveiros, M Martins, I Couto, L Rodrigues, D Machado, I Portugal, ...
Expert review of anti-infective therapy 8 (4), 465-480, 2010
|Gold nanoprobes for multi loci assessment of multi-drug resistant tuberculosis|
P Pedrosa, B Veigas, D Machado, I Couto, M Viveiros, PV Baptista
Tuberculosis 94 (3), 332-337, 2014
|Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery|
E Azzali, D Machado, A Kaushik, F Vacondio, S Flisi, CS Cabassi, ...
Journal of medicinal chemistry 60 (16), 7108-7122, 2017
|Assessment of the BD MGIT TBc identification test for the detection of Mycobacterium tuberculosis complex in a network of mycobacteriology laboratories|
D Machado, J Ramos, I Couto, N Cadir, I Narciso, E Coelho, S Viegas, ...
BioMed research international 2014, 2014