| The mechanism of γ‐secretase dysfunction in familial Alzheimer disease L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ... The EMBO journal 31 (10), 2261-2274, 2012 | 435 | 2012 |
| LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis S Matta, K Van Kolen, R da Cunha, G van den Bogaart, W Mandemakers, ... Neuron 75 (6), 1008-1021, 2012 | 300 | 2012 |
| Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the γ-secretase complex A Tolia, L Chávez-Gutiérrez, B De Strooper Journal of Biological Chemistry 281 (37), 27633-27642, 2006 | 158 | 2006 |
| Glu332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity L Chávez-Gutiérrez, A Tolia, E Maes, T Li, PC Wong, B De Strooper Journal of Biological Chemistry 283 (29), 20096-20105, 2008 | 140 | 2008 |
| Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond B De Strooper, L Chávez Gutiérrez Annual review of pharmacology and toxicology 55, 419-437, 2015 | 117 | 2015 |
| Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease M Szaruga, S Veugelen, M Benurwar, S Lismont, D Sepulveda-Falla, ... Journal of Experimental Medicine 212 (12), 2003-2013, 2015 | 103 | 2015 |
| Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ... Cell 170 (3), 443-456. e14, 2017 | 101 | 2017 |
| Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series NS Ryan, JM Nicholas, PSJ Weston, Y Liang, T Lashley, R Guerreiro, ... The Lancet Neurology 15 (13), 1326-1335, 2016 | 100 | 2016 |
| Familial Alzheimer’s disease mutations in presenilin generate amyloidogenic Aβ peptide seeds S Veugelen, T Saito, TC Saido, L Chávez-Gutiérrez, B De Strooper Neuron 90 (2), 410-416, 2016 | 75 | 2016 |
| Signature amyloid β profiles are produced by different γ-secretase complexes H Acx, L Chávez-Gutiérrez, L Serneels, S Lismont, M Benurwar, N Elad, ... Journal of Biological Chemistry 289 (7), 4346-4355, 2014 | 65 | 2014 |
| Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease FX Guix, T Wahle, K Vennekens, A Snellinx, L Chávez‐Gutiérrez, ... EMBO molecular medicine 4 (7), 660-673, 2012 | 65 | 2012 |
| The dynamic conformational landscape of γ-secretase N Elad, B De Strooper, S Lismont, W Hagen, S Veugelen, M Arimon, ... Journal of cell science 128 (3), 589-598, 2015 | 60 | 2015 |
| Inhibition of β-secretase in vivo via antibody binding to unique loops (D and F) of BACE1 L Zhou, L Chávez-Gutiérrez, K Bockstael, R Sannerud, W Annaert, ... Journal of Biological Chemistry 286 (10), 8677-8687, 2011 | 51 | 2011 |
| Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP FK Wiseman, LJ Pulford, C Barkus, F Liao, E Portelius, R Webb, ... Brain 141 (8), 2457-2474, 2018 | 49 | 2018 |
| Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex L Bammens, L Chávez-Gutiérrez, A Tolia, A Zwijsen, B De Strooper Journal of Biological Chemistry 286 (14), 12271-12282, 2011 | 45 | 2011 |
| Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease NS Ryan, GJ Biessels, L Kim, JM Nicholas, PA Barber, P Walsh, P Gami, ... Neurobiology of aging 36 (12), 3140-3151, 2015 | 42 | 2015 |
| Modulation of γ-and β-secretases as early prevention against Alzheimer’s disease I Voytyuk, B De Strooper, L Chávez-Gutiérrez Biological psychiatry 83 (4), 320-327, 2018 | 36 | 2018 |
| Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration H Acx, L Serneels, E Radaelli, S Muyldermans, C Vincke, E Pepermans, ... EMBO molecular medicine 9 (8), 1088-1099, 2017 | 21 | 2017 |
| Homology Modeling and Site-directed Mutagenesis of Pyroglutamyl Peptidase II INSIGHTS INTO OMEGA-VERSUS AMINOPEPTIDASE SPECIFICITY IN THE M1 FAMILY L Chávez-Gutiérrez, E Matta-Camacho, J Osuna, E Horjales, ... Journal of Biological Chemistry 281 (27), 18581-18590, 2006 | 19 | 2006 |
| Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds K Le Guennec, S Veugelen, O Quenez, M Szaruga, S Rousseau, ... Neurobiology of Disease 104, 97-103, 2017 | 18 | 2017 |
