Patrick Derksen
Patrick Derksen
Associate Professor, UMC Utrecht
Email confirmado em umcutrecht.nl - Página inicial
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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
S Rottenberg, JE Jaspers, A Kersbergen, E van der Burg, AOH Nygren, ...
Proceedings of the National Academy of Sciences 105 (44), 17079-17084, 2008
8692008
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
PWB Derksen, X Liu, F Saridin, H van der Gulden, J Zevenhoven, B Evers, ...
Cancer cell 10 (5), 437-449, 2006
6142006
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
PWB Derksen, E Tjin, HP Meijer, MD Klok, HD Mac Gillavry, ...
Proceedings of the National Academy of Sciences 101 (16), 6122-6127, 2004
3662004
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
B Evers, R Drost, E Schut, M de Bruin, E van der Burg, PWB Derksen, ...
Clinical Cancer Research 14 (12), 3916-3925, 2008
3272008
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids
JML Roodhart, LGM Daenen, ECA Stigter, HJ Prins, J Gerrits, ...
Cancer cell 20 (3), 370-383, 2011
3142011
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
PWB Derksen, RMJ Keehnen, LM Evers, MHJ Van Oers, M Spaargaren, ...
Blood, The Journal of the American Society of Hematology 99 (4), 1405-1410, 2002
3122002
NCAM‐induced focal adhesion assembly: a functional switch upon loss of E‐cadherin
F Lehembre, M Yilmaz, A Wicki, T Schomber, K Strittmatter, D Ziegler, ...
The EMBO journal 27 (19), 2603-2615, 2008
2082008
The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
PWB Derksen, DJJ De Gorter, HP Meijer, RJ Bende, M Van Dijk, ...
Leukemia 17 (4), 764-774, 2003
1952003
The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation
R van der Voort, TEI Taher, PWB Derksen, M Spaargaren, R van der Neut, ...
Academic Press 79, 39-90, 2000
1522000
Intravital microscopy: new insights into metastasis of tumors
E Beerling, L Ritsma, N Vrisekoop, PWB Derksen, J van Rheenen
Journal of cell science 124 (3), 299-310, 2011
1512011
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells
FJH Hoogwater, MW Nijkamp, N Smakman, EJA Steller, BL Emmink, ...
Gastroenterology 138 (7), 2357-2367, 2010
1362010
Chemotherapy enhances metastasis formation via VEGFR-1–expressing endothelial cells
LGM Daenen, JML Roodhart, M van Amersfoort, M Dehnad, W Roessingh, ...
Cancer research 71 (22), 6976-6985, 2011
1352011
Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice
PWB Derksen, TM Braumuller, E van der Burg, M Hornsveld, E Mesman, ...
Disease models & mechanisms 4 (3), 347-358, 2011
1322011
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma
EPM Tjin, RWJ Groen, I Vogelzang, PWB Derksen, MD Klok, HP Meijer, ...
Blood 107 (2), 760-768, 2006
1022006
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance
RCJ Schackmann, M Van Amersfoort, JHI Haarhuis, EJ Vlug, VA Halim, ...
The Journal of clinical investigation 121 (8), 3176-3188, 2011
982011
Re-evaluating the role of FOXOs in cancer
M Hornsveld, TB Dansen, PW Derksen, BMT Burgering
Seminars in cancer biology 50, 90-100, 2018
882018
p120-catenin in cancer–mechanisms, models and opportunities for intervention
RCJ Schackmann, M Tenhagen, RAH van de Ven, PWB Derksen
Journal of cell science 126 (16), 3515-3525, 2013
792013
Modeling metastatic breast cancer in mice
J Jonkers, PWB Derksen
Journal of mammary gland biology and neoplasia 12 (2-3), 191-203, 2007
792007
Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction
MA Hoeve, ADG Krol, K Philippo, PWB Derksen, RA Veenendaal, ...
Molecular Pathology 53 (4), 194, 2000
792000
Fibroblast growth factor receptor 1–transformed mammary epithelial cells are dependent on RSK activity for growth and survival
W Xian, L Pappas, D Pandya, LM Selfors, PW Derksen, M de Bruin, ...
Cancer research 69 (6), 2244-2251, 2009
762009
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Artigos 1–20