Rui Moreira
Rui Moreira
Faculty of Pharmacy, University of Lisbon
Email confirmado em ff.ul.pt
TítuloCitado porAno
Primaquine revisited six decades after its discovery
N Vale, R Moreira, P Gomes
European journal of medicinal chemistry 44 (3), 937-953, 2009
2992009
Indoloquinolines as scaffolds for drug discovery
J Lavrado, R Moreira, A Paulo
Current medicinal chemistry 17 (22), 2348-2370, 2010
1292010
Michael acceptors as cysteine protease inhibitors.
MM Santos, R Moreira
Mini reviews in medicinal chemistry 7 (10), 1040-1050, 2007
1272007
Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug
FP da Cruz, C Martin, K Buchholz, MJ Lafuente-Monasterio, T Rodrigues, ...
Journal of Infectious Diseases 205 (8), 1278-1286, 2012
882012
Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho [2, 3-d] isoxazole-4, 9-diones
MMM Santos, N Faria, J Iley, SJ Coles, MB Hursthouse, ML Martins, ...
Bioorganic & medicinal chemistry letters 20 (1), 193-195, 2010
832010
Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials
MJ Araújo, J Bom, R Capela, C Casimiro, P Chambel, P Gomes, J Iley, ...
Journal of medicinal chemistry 48 (3), 888-892, 2005
762005
Targeting COPD: advances on low‐molecular‐weight inhibitors of human neutrophil elastase
SD Lucas, E Costa, RC Guedes, R Moreira
Medicinal research reviews 33 (S1), E73-E101, 2013
722013
Metabolism of primaquine by liver homogenate fractions: evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to …
L Constantino, P Paixao, R Moreira, MJ Portela, VE Do Rosario, J Iley
Experimental and Toxicologic Pathology 51 (4-5), 299-303, 1999
671999
Targeting the liver stage of malaria parasites: a yet unmet goal
T Rodrigues, M Prudêncio, R Moreira, MM Mota, F Lopes
Journal of medicinal chemistry 55 (3), 995-1012, 2011
652011
Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy
R Capela, GG Cabal, PJ Rosenthal, J Gut, MM Mota, R Moreira, F Lopes, ...
Antimicrobial agents and chemotherapy 55 (10), 4698-4706, 2011
652011
Synthesis of imidazolidin-4-one and 1H-imidazo [2, 1-a] isoindole-2, 5 (3H, 9bH)-dione derivatives of primaquine: scope and limitations
P Gomes, MJ Araújo, M Rodrigues, N Vale, Z Azevedo, J Iley, P Chambel, ...
Tetrahedron 60 (26), 5551-5562, 2004
652004
Design, synthesis and stability of N-acyloxymethyl-and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors
A Clemente, A Domingos, AP Grancho, J Iley, R Moreira, J Neres, ...
Bioorganic & medicinal chemistry letters 11 (8), 1065-1068, 2001
642001
Cyclization-activated prodrugs
P Gomes, N Vale, R Moreira
Molecules 12 (11), 2484-2506, 2007
592007
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition
R Capela, R Oliveira, LM Gonçalves, A Domingos, J Gut, PJ Rosenthal, ...
Bioorganic & medicinal chemistry letters 19 (12), 3229-3232, 2009
572009
Dipeptide vinyl sultams: Synthesis via the Wittig–Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum
C Valente, RC Guedes, R Moreira, J Iley, J Gut, PJ Rosenthal
Bioorganic & medicinal chemistry letters 16 (15), 4115-4119, 2006
572006
Amidomethylation of amodiaquine: antimalarial N-Mannich base derivatives
F Lopes, R Capela, JO Gonçaves, PN Horton, MB Hursthouse, J Iley, ...
Tetrahedron letters 45 (41), 7663-7666, 2004
572004
Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of …
MJ Portela, R Moreira, E Valente, L Constantino, J Iley, J Pinto, R Rosa, ...
Pharmaceutical research 16 (6), 949-955, 1999
571999
Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins
KK Hanson, AS Ressurreição, K Buchholz, M Prudêncio, ...
Proceedings of the National Academy of Sciences 110 (30), E2838-E2847, 2013
552013
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity
J Lavrado, A Paulo, J Gut, PJ Rosenthal, R Moreira
Bioorganic & medicinal chemistry letters 18 (4), 1378-1381, 2008
552008
Incorporation of basic side chains into cryptolepine scaffold: Structure− antimalarial activity relationships and mechanistic studies
J Lavrado, GG Cabal, M Prudêncio, MM Mota, J Gut, PJ Rosenthal, ...
Journal of medicinal chemistry 54 (3), 734-750, 2011
522011
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