Neuronal activity enhances tau propagation and tau pathology in vivo JW Wu, SA Hussaini, IM Bastille, GA Rodriguez, A Mrejeru, K Rilett, ... Nature neuroscience 19 (8), 1085-1092, 2016 | 692 | 2016 |
Selective vulnerability in neurodegenerative diseases H Fu, J Hardy, KE Duff Nature neuroscience 21 (10), 1350-1358, 2018 | 469 | 2018 |
scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses J Wang, A Ma, Y Chang, J Gong, Y Jiang, R Qi, C Wang, H Fu, Q Ma, ... Nature communications 12 (1), 1882, 2021 | 401 | 2021 |
Tau pathology induces excitatory neuron loss, grid cell dysfunction, and spatial memory deficits reminiscent of early Alzheimer’s disease H Fu, GA Rodriguez, M Herman, S Emrani, E Nahmani, G Barrett, ... Neuron 93 (3), 533-541. e5, 2017 | 261 | 2017 |
Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers S Li, M Jin, D Zhang, T Yang, T Koeglsperger, H Fu, DJ Selkoe Neuron 77 (5), 929-941, 2013 | 207 | 2013 |
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology H Fu, A Possenti, R Freer, Y Nakano, NC Hernandez Villegas, M Tang, ... Nature neuroscience 22 (1), 47-56, 2019 | 186 | 2019 |
Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia H Fu, B Liu, JL Frost, S Hong, M Jin, B Ostaszewski, GM Shankar, ... Glia, 2012 | 185 | 2012 |
Amyloid-β Immunotherapy for Alzheimer's Disease HJ Fu, B Liu, JL Frost, CA Lemere CNS & neurological disorders drug targets 9 (2), 197, 2010 | 147 | 2010 |
Novel dimeric acetylcholinesterase inhibitor bis (7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors W Li, R Pi, HHN Chan, H Fu, NTK Lee, HW Tsang, Y Pu, DC Chang, C Li, ... Journal of Biological Chemistry 280 (18), 18179-18188, 2005 | 142 | 2005 |
Bis (7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels H Fu, W Li, Y Lao, J Luo, NTK Lee, KKW Kan, HW Tsang, KWK Tsim, ... Journal of neurochemistry 98 (5), 1400-1410, 2006 | 123 | 2006 |
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies M Kenigsbuch, P Bost, S Halevi, Y Chang, S Chen, Q Ma, R Hajbi, ... Nature neuroscience 25 (7), 876-886, 2022 | 97 | 2022 |
Promising anti-Alzheimer’s dimer bis (7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity H Fu, W Li, J Luo, NTK Lee, M Li, KWK Tsim, Y Pang, MBH Youdim, ... Biochemical and biophysical research communications 366 (3), 631-636, 2008 | 86 | 2008 |
scREAD: a single-cell RNA-Seq database for Alzheimer's disease J Jiang, C Wang, R Qi, H Fu, Q Ma Iscience 23 (11), 2020 | 78 | 2020 |
Aluminum-induced apoptosis in cultured cortical neurons and its effect on SAPK/JNK signal transduction pathway HJ Fu, QS Hu, ZN Lin, TL Ren, H Song, CK Cai, SZ Dong Brain research 980 (1), 11-23, 2003 | 75 | 2003 |
MER5101, a novel Aβ1-15: DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice B Liu, JL Frost, J Sun, H Fu, S Grimes, P Blackburn, CA Lemere Journal of Neuroscience 33 (16), 7027-7037, 2013 | 68 | 2013 |
Synergistic neuroprotection by bis (7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase W Li, J Xue, C Niu, H Fu, CSC Lam, J Luo, HHN Chan, H Xue, KKW Kan, ... Molecular pharmacology 71 (5), 1258-1267, 2007 | 64 | 2007 |
F‐box/LRR‐repeat protein 7 is genetically associated with Alzheimer's disease G Tosto, H Fu, BN Vardarajan, JH Lee, R Cheng, D Reyes‐Dumeyer, ... Annals of clinical and translational neurology 2 (8), 810-820, 2015 | 59 | 2015 |
Promising multifunctional anti-Alzheimer's dimer bis (7)-Cognitin acting as an activator of protein kinase C regulates activities of α-secretase and BACE-1 concurrently H Fu, J Dou, W Li, W Cui, S Mak, Q Hu, J Luo, CSC Lam, Y Pang, ... European journal of pharmacology 623 (1-3), 14-21, 2009 | 50 | 2009 |
Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups Q Hu, H Fu, T Ren, S Wang, W Zhou, H Song, Y Han, S Dong Neurotoxicology 29 (4), 675-681, 2008 | 47 | 2008 |
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase MN Vo, M Terrey, JW Lee, B Roy, JJ Moresco, L Sun, H Fu, Q Liu, ... Nature 557 (7706), 510-515, 2018 | 46 | 2018 |