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Dr. Adrian Sievers-Engler
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Targeting the gatekeeper MET146 of C-Jun N-Terminal Kinase 3 induces a bivalent halogen/chalcogen bond
A Lange, M Günther, FM Büttner, MO Zimmermann, J Heidrich, ...
Journal of the American Chemical Society 137 (46), 14640-14652, 2015
852015
Trisubstituted imidazoles with a rigidized hinge binding motif act as single digit nM inhibitors of clinically relevant EGFR L858R/T790M and L858R/T790M/C797S mutants: An …
M Juchum, M Günther, E Doering, A Sievers-Engler, M Lämmerhofer, ...
Journal of Medicinal Chemistry, 2017
732017
Tri-and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3
F Muth, A El-Gokha, F Ansideri, M Eitel, E Döring, A Sievers-Engler, ...
Journal of medicinal chemistry 60 (2), 594-607, 2017
462017
Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides
H Gerhardt, A Sievers-Engler, G Jahanshah, Z Pataj, F Ianni, H Gross, ...
Journal of Chromatography A 1428, 280-291, 2016
392016
Surface-crosslinked poly (3-mercaptopropyl) methylsiloxane-coatings on silica as new platform for low-bleed mass spectrometry-compatible functionalized stationary phases …
A Zimmermann, J Horak, A Sievers-Engler, C Sanwald, W Lindner, ...
Journal of Chromatography A 1436, 73-83, 2016
332016
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target …
NM Walter, HK Wentsch, M Bührmann, SM Bauer, E Döring, ...
Journal of medicinal chemistry 60 (19), 8027-8054, 2017
302017
Papain-functionalized gold nanoparticles as heterogeneous biocatalyst for bioanalysis and biopharmaceuticals analysis
S Liu, M Höldrich, A Sievers-Engler, J Horak, M Lämmerhofer
Analytica Chimica Acta 963, 33-43, 2017
272017
Gold nanoparticle-conjugated pepsin for efficient solution-like heterogeneous biocatalysis in analytical sample preparation protocols
M Höldrich, A Sievers-Engler, M Lämmerhofer
Analytical and bioanalytical chemistry 408 (20), 5415-5427, 2016
262016
Molecular Recognition and Visual Detection of G‐Quadruplexes by a Dicarbocyanine Dye
B Karg, A Funke, A Ficht, A Sievers‐Engler, M Lämmerhofer, K Weisz
Chemistry-A European Journal 21 (39), 13802-13811, 2015
232015
Surface-anchored counterions on weak chiral anion-exchangers accelerate separations and improve their compatibility for mass-spectrometry-hyphenation
U Woiwode, A Sievers-Engler, A Zimmermann, W Lindner, ...
Journal of Chromatography A 1503, 21-31, 2017
172017
Preparation of fluorescent labeled gentamicin as biological tracer and its characterization by liquid chromatography and high resolution mass spectrometry
U Woiwode, A Sievers-Engler, M Lämmerhofer
Journal of pharmaceutical and biomedical analysis 121, 307-315, 2016
152016
Selective Targeting of G‐Quadruplex Structures by a Benzothiazole‐Based Binding Motif
I Buchholz, B Karg, J Dickerhoff, A Sievers‐Engler, M Lämmerhofer, ...
Chemistry-A European Journal 23 (24), 5814-5823, 2017
112017
Mastering analytical challenges for the characterization of pentacyclic triterpene mono- and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC …
C Nicolaus, A Sievers-Engler, R Murillo, M D'Ambrosio, M Lämmerhofer, ...
Journal of pharmaceutical and biomedical analysis 118, 195-205, 2016
92016
Ligand–receptor binding increments in enantioselective liquid chromatography
A Sievers-Engler, W Lindner, M Lämmerhofer
Journal of Chromatography A 1363, 79-88, 2014
62014
UHPLC-ESI-MS/MS Assay for Quantification of Endocannabinoids in Cerebrospinal Fluid Using Surrogate Calibrant and Surrogate Matrix Approaches
E Aydin, M Cebo, J Mielnik, H Richter, R Schüle, A Sievers-Engler, ...
Journal of Pharmaceutical and Biomedical Analysis, 115090, 2022
52022
Sample injector
A Sievers-Engler
US Patent 11,408,865, 2022
42022
Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase Chromatography
W Lindner, P Franco, M Lämmerhofer, A Sievers-Engler, H Gross, ...
32016
UHPLC-QTOF-MS as a valuable tool for the identification of novel faradiol fatty acid diesters of Calendula officinalis flowers
C Nicolaus, A Sievers-Engler, R Murillo, M Lämmerhofer, I Merfort
Planta Medica 81 (16), PW_177, 2015
32015
Automatic sample concentrating unit
A Sievers-Engler
US Patent App. 17/304,344, 2021
12021
Quick liquid exchange in liquid chromatography
A Sievers-Engler
US Patent App. 15/931,152, 2020
12020
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