Anticancer steroids: linking natural and semi-synthetic compounds JAR Salvador, JFS Carvalho, MAC Neves, SM Silvestre, AJ Leitao, ... Natural product reports 30 (2), 324-374, 2013 | 290 | 2013 |
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity RC Santos, JAR Salvador, S Marín, M Cascante Bioorganic & medicinal chemistry 17 (17), 6241-6250, 2009 | 174 | 2009 |
Highlights in BACE1 inhibitors for Alzheimer's disease treatment JRM Coimbra, DFF Marques, SJ Baptista, CMF Pereira, PI Moreira, ... Frontiers in chemistry 6, 178, 2018 | 164 | 2018 |
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment JAR Salvador, AS Leal, AS Valdeira, BMF Goncalves, DPS Alho, ... European Journal of Medicinal Chemistry 142, 95-130, 2017 | 157 | 2017 |
Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs JAR Salvador, VM Moreira, BMF Gonçalves, AS Leal, Y Jing Natural product reports 29 (12), 1463-1479, 2012 | 154 | 2012 |
Allylic and benzylic oxidation reactions with sodium chlorite SM Silvestre, JAR Salvador Tetrahedron 63 (11), 2439-2445, 2007 | 131 | 2007 |
Copper-catalysed allylic oxidation of Δ5-steroids by t-butyl hydroperoxide JAR Salvador, MLS Melo, ASC Neves Tetrahedron letters 38 (1), 119-122, 1997 | 126 | 1997 |
Bismuth compounds in medicinal chemistry JAR Salvador, SAC Figueiredo, RMA Pinto, SM Silvestre Future medicinal chemistry 4 (11), 1495-1523, 2012 | 114 | 2012 |
The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using surface functionalised silica supported metal catalysts JAR Salvador, JH Clark Green Chemistry 4 (4), 352-356, 2002 | 100 | 2002 |
Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide JAR Salvador, SM Silvestre Tetrahedron letters 46 (15), 2581-2584, 2005 | 97 | 2005 |
Recent advances of bismuth (III) salts in organic chemistry: application to the synthesis of heterocycles of pharmaceutical interest JAR Salvador, R Pinto, SM Silvestre Current Organic Synthesis 6 (4), 426-470, 2009 | 95 | 2009 |
Steroidal 5α-reductase and 17α-hydroxylase/17, 20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases JAR Salvador, RMA Pinto, SM Silvestre The Journal of steroid biochemistry and molecular biology 137, 199-222, 2013 | 88 | 2013 |
Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid RC Santos, JAR Salvador, S Marín, M Cascante, JN Moreira, TCP Dinis Bioorganic & medicinal chemistry 18 (12), 4385-4396, 2010 | 88 | 2010 |
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors VMA Moreira, TS Vasaitis, VCO Njar, JAR Salvador steroids 72 (14), 939-948, 2007 | 80 | 2007 |
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells AS Leal, R Wang, JAR Salvador, Y Jing Bioorganic & medicinal chemistry 20 (19), 5774-5786, 2012 | 73 | 2012 |
Catalytic oxidative processes in steroid chemistry: Allylic oxidation, β-selective epoxidation, alcohol oxidation and remote functionalization reactions JAR Salvador, SM Silvestre, VM Moreira Current Organic Chemistry 10 (17), 2227-2257, 2006 | 71 | 2006 |
Highlights of pentacyclic triterpenoids in the cancer settings JAR Salvador, AS Leal, DPS Alho, BMF Gonçalves, AS Valdeira, ... Studies in Natural Products Chemistry 41, 33-73, 2014 | 70 | 2014 |
Oxidations with potassium permanganate—metal sulphates and nitrates. β-Selective epoxidation of Δ5-unsaturated steroids JAR Salvador, MLS Melo, ASC Neves Tetrahedron letters 37 (5), 687-690, 1996 | 69 | 1996 |
Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine MC Sousa, R Varandas, RC Santos, M Santos-Rosa, V Alves, ... PloS one 9 (3), e89939, 2014 | 68 | 2014 |
CYP17 inhibitors for prostate cancer treatment-an update VM Moreira, JAR Salvador, TS Vasaitis, VCO Njar Current Medicinal Chemistry 15 (9), 868-899, 2008 | 67 | 2008 |