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Emanuel Candeias
Emanuel Candeias
PhD, CNC - Center for Neuroscience and Cell Biology, University of Coimbra
Email confirmado em student.uc.pt
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Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation
SC Correia, RX Santos, C Carvalho, S Cardoso, E Candeias, MS Santos, ...
Brain research 1441, 64-78, 2012
2472012
Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
AI Duarte, E Candeias, SC Correia, RX Santos, C Carvalho, S Cardoso, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (4), 527-541, 2013
1752013
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease
MPI Plácido AI, Pereira CM, Duarte AI, Candeias E, Correia SC, Santos RX ...
Biochim Biophys Acta 1842 (9), 1444-53, 2014
129*2014
Insulin as a bridge between type 2 diabetes and Alzheimer disease–how anti-diabetics could be a solution for dementia
I Sebastião, E Candeias, MS Santos, CR de Oliveira, PI Moreira, ...
Frontiers in endocrinology 5, 2014
1132014
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide
EM Candeias, IC Sebastião, SM Cardoso, SC Correia, CI Carvalho, ...
World journal of diabetes 6 (6), 807, 2015
1072015
The impairment of insulin signaling in Alzheimer's disease
E Candeias, AI Duarte, C Carvalho, SC Correia, S Cardoso, RX Santos, ...
IUBMB life 64 (12), 951-957, 2012
1052012
Brain GLP-1/IGF-1 signaling and autophagy mediate exendin-4 protection against apoptosis in type 2 diabetic rats
E Candeias, I Sebastião, S Cardoso, C Carvalho, MS Santos, CR Oliveira, ...
Molecular neurobiology 55, 4030-4050, 2018
842018
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
L Piemontese, D Tomás, A Hiremathad, V Capriati, E Candeias, ...
Journal of enzyme inhibition and medicinal chemistry 33 (1), 1212-1224, 2018
722018
Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative …
AI Duarte, E Candeias, IN Alves, D Mena, DF Silva, NJ Machado, ...
International journal of molecular sciences 21 (5), 1746, 2020
602020
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
DF Silva, E Candeias, AR Esteves, JD Magalhães, IL Ferreira, ...
Journal of Neuroinflammation 17, 1-18, 2020
532020
The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
C Carvalho, SC Correia, S Cardoso, AI Placido, E Candeias, AI Duarte, ...
Expert review of neurotherapeutics 15 (8), 867-884, 2015
522015
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins
MPI Cardoso S, Correia SC, Santos RX, Carvalho C, Candeias E, Duarte AI ...
Curr Mol Med 13 (4), 586-601, 2013
402013
Alzheimer disease as a vascular disorder: Where do mitochondria fit?
SC Correia, RX Santos, S Cardoso, C Carvalho, E Candeias, AI Duarte, ...
Experimental gerontology 47 (11), 878-886, 2012
372012
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
AR Esteves, MF Munoz-Pinto, D Nunes-Costa, E Candeias, DF Silva, ...
Gut 72 (1), 73-89, 2023
352023
Middle-aged diabetic females and males present distinct susceptibility to Alzheimer disease-like pathology
E Candeias, AI Duarte, I Sebastião, MA Fernandes, AI Plácido, ...
Molecular Neurobiology 54, 6471-6489, 2017
352017
Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
S Cardoso, S Correia, C Carvalho, E Candeias, AI Plácido, AI Duarte, ...
Journal of bioenergetics and biomembranes, 1-13, 2014
342014
New multitarget hybrids bearing tacrine and phenylbenzothiazole motifs as potential drug candidates for Alzheimer’s disease
R Rajeshwari, K Chand, E Candeias, SM Cardoso, S Chaves, MA Santos
Molecules 24 (3), 587, 2019
282019
Modulation of endoplasmic reticulum stress: an opportunity to prevent neurodegeneration?
AI Placido, C MF Pereira, A I Duarte, E Candeias, S C Correia, ...
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2015
282015
Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug
K Chand, E Candeias, SM Cardoso, S Chaves, MA Santos
Metallomics 10 (10), 1460-1475, 2018
272018
Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!
S C Correia, C Carvalho, S Cardoso, R X Santos, A I Plácido, E Candeias, ...
Current pharmaceutical design 19 (38), 6809-6822, 2013
272013
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