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Srinivas Niranj Chandrasekaran
Srinivas Niranj Chandrasekaran
Outros nomesSrinivas Niranj Chandrasekharan, Niranj Chandrasekaran
Postdoctoral Associate, Broad Institute of MIT and Harvard
Email confirmado em broadinstitute.org - Página inicial
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Ano
Image-based profiling for drug discovery: due for a machine-learning upgrade?
SN Chandrasekaran, H Ceulemans, JD Boyd, AE Carpenter
Nature Reviews Drug Discovery 20 (2), 145-159, 2021
2412021
Rational design of a ligand-controlled protein conformational switch
O Dagliyan, D Shirvanyants, A Karginov, F Ding, SN Chandrasekaran, ...
Biophysical Journal 104 (2), 18a-19a, 2013
1232013
Functional class I and II amino acid-activating enzymes can be coded by opposite strands of the same gene
L Martinez-Rodriguez, O Erdogan, M Jimenez-Rodriguez, ...
Journal of Biological Chemistry 290 (32), 19710-19725, 2015
712015
Morphology and gene expression profiling provide complementary information for mapping cell state
GP Way, T Natoli, A Adeboye, L Litichevskiy, A Yang, X Lu, JC Caicedo, ...
Cell systems 13 (11), 911-923. e9, 2022
582022
The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed
CW Carter, L Li, V Weinreb, M Collier, K Gonzalez-Rivera, ...
Biology Direct 9, 1-23, 2014
582014
Statistical evaluation of the Rodin–Ohno hypothesis: Sense/antisense coding of ancestral Class I and II aminoacyl-tRNA synthetases
SN Chandrasekaran, GG Yardimci, O Erdogan, J Roach, CW Carter Jr
Molecular Biology and Evolution 30 (7), 1588-1604, 2013
502013
Optimizing the Cell Painting assay for image-based profiling
BA Cimini, SN Chandrasekaran, M Kost-Alimova, L Miller, A Goodale, ...
Nature protocols 18 (7), 1981-2013, 2023
472023
Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif
V Weinreb, L Li, SN Chandrasekaran, P Koehl, M Delarue, CW Carter
Journal of Biological Chemistry 289 (7), 4367-4376, 2014
382014
Molecular dynamics simulations of human and dog gastric lipases: Insights into domain movements
A Selvan, C Seniya, SN Chandrasekaran, N Siddharth, S Anishetty, ...
FEBS letters 584 (22), 4599-4605, 2010
312010
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations
SN Chandrasekaran, BA Cimini, A Goodale, L Miller, M Kost-Alimova, ...
Nature Methods, 1-8, 2024
302024
JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations
SN Chandrasekaran, J Ackerman, E Alix, DM Ando, J Arevalo, M Bennion, ...
Biorxiv, 2023.03. 23.534023, 2023
292023
A modified PATH algorithm rapidly generates transition states comparable to those found by other well established algorithms
SN Chandrasekaran, J Das, NV Dokholyan, CW Carter
Structural Dynamics 3 (1), 2016
262016
Combining multi-mutant and modular thermodynamic cycles to measure energetic coupling networks in enzyme catalysis
CW Carter, SN Chandrasekaran, V Weinreb, L Li, T Williams
Structural Dynamics 4 (3), 2017
162017
Adding torsional interaction terms to the Anisotropic Network Model improves the PATH performance, enabling detailed comparison with experimental rate data
SN Chandrasekaran, CW Carter Jr
Struct. Dyn 4 (032103), 10.1063, 2017
16*2017
Pycytominer: Data processing functions for profiling perturbations
G Way, SN Chandrasekaran, M Bornholdt, S Fleming, H Tsang, ...
GitHub, 2021
72021
nELISA: A high-throughput, high-plex platform enables quantitative profiling of the secretome
M Dagher, G Ongo, N Robichaud, J Kong, W Rho, I Teahulos, A Tavakoli, ...
bioRxiv, 2023.04. 17.535914, 2023
52023
Reproducible image-based profiling with Pycytominer
E Serrano, SN Chandrasekaran, D Bunten, KI Brewer, J Tomkinson, ...
ArXiv, 2023
42023
Thermodynamic impacts of combinatorial mutagenesis on protein conformational stability: precise, high-throughput measurement by Thermofluor
V Weinreb, G Weinreb, SN Chandrasekaran, J Das, NV Dokholyan, ...
BioRxiv, 591495, 2019
32019
Microcalorimetry reveals multi-state thermal denaturation of G. stearothermophilus tryptophanyl-tRNA synthetase
SN Chandrasekaran, J Das, NV Dokholyan, CW Carter
Structural Dynamics 10 (4), 2023
12023
PATH: A computational algorithm that rapidly identifies protein conformational transition states and transition pathways
SN Chandrasekaran
66th Annual Meeting, 2016
2016
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Artigos 1–20