Laura Orellana
Laura Orellana
Stockholm University
No verified email
TitleCited byYear
FlexServ: an integrated tool for the analysis of protein flexibility
J Camps, O Carrillo, A Emperador, L Orellana, A Hospital, M Rueda, ...
Bioinformatics 25 (13), 1709-1710, 2009
802009
Correlated motions are a fundamental property of β-sheets
RB Fenwick, L Orellana, S Esteban-Martín, M Orozco, X Salvatella
Nature communications 5, 4070, 2014
532014
Approaching elastic network models to molecular dynamics flexibility
L Orellana, M Rueda, C Ferrer-Costa, JR Lopez-Blanco, P Chacón, ...
Journal of Chemical Theory and Computation, 2010
532010
Coarse-grained Representation of Protein Flexibility. Foundations, Successes, and Shortcomings.
M OROZCO, L ORELLANA, AN Naganathan, A Emperador, O Carrillo, ...
Computational Chemistry Methods in Structural Biology 85, 183, 2011
302011
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
ZA Binder, AH Thorne, S Bakas, EP Wileyto, M Bilello, H Akbari, ...
Cancer cell 34 (1), 163-177. e7, 2018
262018
Finding Conformational Transition Pathways from Discrete Molecular Dynamics Simulations
P Sfriso, A Emperador, L Orellana, A Hospital, JL Gelpí, M Orozco
Journal of Chemical Theory and Computation, 0
26
Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations
L Orellana, O Yoluk, O Carrillo, M Orozco, E Lindahl
Nature communications 7, 12575, 2016
252016
Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ...
Cancer cell 35 (3), 504-518. e7, 2019
122019
Oncogenic mutations at the EGFR ectodomain structurally converge to remove a steric hindrance on a kinase-coupled cryptic epitope
L Orellana, AH Thorne, R Lema, J Gustavsson, AD Parisian, TN Cordeiro, ...
Proceedings of the National Academy of Sciences, 201821442, 2019
42019
Oncogenic mutations of the EGF-Receptor ectodomain reveal an unexpected mechanism for ligand-independent activation
L Orellana, A Hospital, M Orozco
biorXiv, 2014
42014
eBDIMS server: protein transition pathways with ensemble analysis in 2D-motion spaces
L Orellana, J Gustavsson, C Bergh, O Yoluk, E Lindahl
Bioinformatics, 2019
22019
Protein dynamics studied by coarse-grained and atomistic theoretical approaches
L Orellana
Universitat de Barcelona, 2014
22014
Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
L Orellana
Molecular & cellular oncology 6 (5), e1630798, 2019
12019
understanding protein dynamics with coarsegrained models: from structures to disease: p25-3
L Orellana, M Orozco
The Febs Journal 279, 528, 2012
12012
Erratum: Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (Cancer Cell (2019) 35 (3)(504–518. e7 …
J Ma, JA Benitez, J Li, S Miki, CP de Albuquerque, T Galatro, L Orellana, ...
Cancer Cell 35 (5), 2019
2019
Understanding the Conformational Dynamics of a Pentameric Ligand-Gated Ion Channel through Markov State Modeling
CC Bergh, L Orellana, RJ Howard, E Lindahl
Biophysical Journal 116 (3), 395a-396a, 2019
2019
Allosteric Modulation via Transmembrane Interfaces in a Pentameric Ligand-Gated Ion Channel
RJ Howard, Y Zhuang, S Nakamura, M Lycksell, H Kiik, U Rovšnik, ...
Biophysical Journal 116 (3), 245a-246a, 2019
2019
Large-scale conformational changes and protein function: breaking the in silico barrier
L Orellana
Frontiers in molecular biosciences 6, 117, 2019
2019
The eBDIMS path-sampling server: generation, classification and interactive visualization of protein ensembles and transition pathways in 2D-motion space
L Orellana, J Gustavsson, C Bergh, O Yoluk, E Lindahl
arXiv preprint arXiv:1803.06873, 2018
2018
ALCOHOL MODULATION VIA ALLOSTERIC TRANSMEMBRANE SITES IN PENTAMERIC LIGAND-GATED ION CHANNELS
RJ Howard, SA Heusser, Y Zhuang, M Lycksell, G Klement, L Orellana, ...
Alcoholism: Clinical and Experimental Research 42, 60A-60A, 2018
2018
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