| Premature ageing in mice expressing defective mitochondrial DNA polymerase A Trifunovic, A Wredenberg, M Falkenberg, JN Spelbrink, AT Rovio, ... Nature 429 (6990), 417-423, 2004 | 3048 | 2004 |
| Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016 | 1653 | 2016 |
| Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria JN Spelbrink, FY Li, V Tiranti, K Nikali, QP Yuan, M Tariq, S Wanrooij, ... Nature genetics 28 (3), 223-231, 2001 | 1005 | 2001 |
| Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production A Trifunovic, A Hansson, A Wredenberg, AT Rovio, E Dufour, I Khvorostov, ... Proceedings of the National Academy of Sciences 102 (50), 17993-17998, 2005 | 643 | 2005 |
| Coupled leading-and lagging-strand synthesis of mammalian mitochondrial DNA IJ Holt, HE Lorimer, HT Jacobs Cell 100 (5), 515-524, 2000 | 579 | 2000 |
| Mitochondria are physiologically maintained at close to 50 C D Chrétien, P Bénit, HH Ha, S Keipert, R El-Khoury, YT Chang, ... PLoS biology 16 (1), e2003992, 2018 | 380 | 2018 |
| Nucleotide sequence and gene organization of sea urchin mitochondrial DNA HT Jacobs, DJ Elliott, VB Math, A Farquharson Journal of molecular biology 202 (2), 185-217, 1988 | 379 | 1988 |
| A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness FM Reid, GA Vernham, HT Jacobs Human mutation 3 (3), 243-247, 1994 | 355 | 1994 |
| Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication MY Yang, M Bowmaker, A Reyes, L Vergani, P Angeli, E Gringeri, ... Cell 111 (4), 495-505, 2002 | 354 | 2002 |
| Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand T Yasukawa, A Reyes, TJ Cluett, MY Yang, M Bowmaker, HT Jacobs, ... The EMBO journal 25 (22), 5358-5371, 2006 | 329 | 2006 |
| Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone M Bowmaker, MY Yang, T Yasukawa, A Reyes, HT Jacobs, JA Huberman, ... Journal of Biological Chemistry 278 (51), 50961-50969, 2003 | 295 | 2003 |
| Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders JA Smeitink, M Zeviani, DM Turnbull, HT Jacobs Cell metabolism 3 (1), 9-13, 2006 | 275 | 2006 |
| Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes. DR Dunbar, PA Moonie, HT Jacobs, IJ Holt Proceedings of the National Academy of Sciences 92 (14), 6562-6566, 1995 | 240 | 1995 |
| In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells JN Spelbrink, JM Toivonen, GAJ Hakkaart, JM Kurkela, HM Cooper, ... Journal of Biological Chemistry 275 (32), 24818-24828, 2000 | 230 | 2000 |
| Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility AT Rovio, DR Marchington, S Donat, HC Schuppe, J Abel, E Fritsche, ... Nature genetics 29 (3), 261-262, 2001 | 223 | 2001 |
| A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA T Yasukawa, MY Yang, HT Jacobs, IJ Holt Molecular cell 18 (6), 651-662, 2005 | 220 | 2005 |
| Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter A Rubio-Cosials, JF Sydow, N Jiménez-Menéndez, P Fernández-Millán, ... Nature structural & molecular biology 18 (11), 1281-1289, 2011 | 217 | 2011 |
| Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production YL Chua, E Dufour, EP Dassa, P Rustin, HT Jacobs, CT Taylor, T Hagen Journal of Biological Chemistry 285 (41), 31277-31284, 2010 | 205 | 2010 |
| Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells JLO Pohjoismäki, S Wanrooij, AK Hyvärinen, S Goffart, IJ Holt, ... Nucleic acids research 34 (20), 5815-5828, 2006 | 184 | 2006 |
| Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation DJM Fernandez-Ayala, A Sanz, S Vartiainen, KK Kemppainen, ... Cell metabolism 9 (5), 449-460, 2009 | 180 | 2009 |
