| The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease PJ Cheng-Hathaway, EG Reed-Geaghan, TR Jay, BT Casali, SM Bemiller, ... Molecular neurodegeneration 13, 1-12, 2018 | 194 | 2018 |
| Therapeutic potential of nuclear receptor agonists in Alzheimer's disease M Moutinho, GE Landreth Journal of lipid research 58 (10), 1937-1949, 2017 | 74 | 2017 |
| Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond M Moutinho, MJ Nunes, E Rodrigues Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2016 | 74 | 2016 |
| INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia AP Tsai, PBC Lin, C Dong, M Moutinho, BT Casali, Y Liu, BT Lamb, ... Neurobiology of disease 153, 105303, 2021 | 68 | 2021 |
| Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux MJ Nunes, M Moutinho, MJ Gama, CMP Rodrigues, E Rodrigues PloS one 8 (1), e53394, 2013 | 65 | 2013 |
| Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining I Palmela, H Sasaki, FL Cardoso, M Moutinho, KS Kim, D Brites, MA Brito Frontiers in cellular neuroscience 6, 22, 2012 | 63 | 2012 |
| Nuclear receptors as therapeutic targets for neurodegenerative diseases: lost in translation M Moutinho, JF Codocedo, SS Puntambekar, GE Landreth Annual review of pharmacology and toxicology 59, 237-261, 2019 | 53 | 2019 |
| Characterization of new G protein-coupled adenine receptors in mouse and hamster D Thimm, M Knospe, A Abdelrahman, M Moutinho, BBA Alsdorf, ... Purinergic signalling 9, 415-426, 2013 | 49 | 2013 |
| The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease M Moutinho, SS Puntambekar, AP Tsai, I Coronel, PB Lin, BT Casali, ... Science translational medicine 14 (637), eabl7634, 2022 | 47 | 2022 |
| The mevalonate pathway in neurons: it's not just about cholesterol M Moutinho, MJ Nunes, E Rodrigues Experimental cell research 360 (1), 55-60, 2017 | 46 | 2017 |
| PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease AP Tsai, C Dong, PBC Lin, EJ Messenger, BT Casali, M Moutinho, Y Liu, ... Genome Medicine 14 (1), 17, 2022 | 43 | 2022 |
| Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk M Moutinho, MJ Nunes, JC Correia, MJ Gama, M Castro-Caldas, ... Scientific reports 6 (1), 30928, 2016 | 37 | 2016 |
| CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease SS Puntambekar, M Moutinho, PBC Lin, V Jadhav, D Tumbleson-Brink, ... Molecular neurodegeneration 17 (1), 47, 2022 | 34 | 2022 |
| Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice VS Jadhav, PBC Lin, T Pennington, GV Di Prisco, AJ Jannu, G Xu, ... Molecular neurodegeneration 15, 1-16, 2020 | 30 | 2020 |
| Cholesterol 24S-hydroxylase overexpression inhibits the liver X receptor (LXR) pathway by activating small guanosine triphosphate-binding proteins (sGTPases) in neuronal cells M Moutinho, MJ Nunes, AQ Gomes, MJ Gama, A Cedazo-Minguez, ... Molecular neurobiology 51, 1489-1503, 2015 | 30 | 2015 |
| Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter I Milagre, MJ Nunes, M Castro‐Caldas, M Moutinho, MJ Gama, ... Journal of neurochemistry 120 (2), 220-229, 2012 | 21 | 2012 |
| Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination I Milagre, MJ Nunes, M Moutinho, I Rivera, A Fuso, S Scarpa, MJ Gama, ... Journal of Alzheimer's Disease 22 (4), 1209-1221, 2010 | 19 | 2010 |
| INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease PBC Lin, APY Tsai, D Soni, A Lee‐Gosselin, M Moutinho, ... Alzheimer's & Dementia 19 (6), 2528-2537, 2023 | 18 | 2023 |
| Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells I Milagre, M Olin, MJ Nunes, M Moutinho, A Lövgren-Sandblom, MJ Gama, ... Neurochemistry international 60 (2), 192-198, 2012 | 17 | 2012 |
| Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway MJ Nunes, M Moutinho, I Milagre, MJ Gama, E Rodrigues Journal of Lipid Research 53 (9), 1910-1919, 2012 | 13 | 2012 |
