Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells Á Raya, I Rodríguez-Pizà, G Guenechea, R Vassena, S Navarro, ... Nature 460 (7251), 53-59, 2009 | 954 | 2009 |
Distinct classes of human stem cells that differ in proliferative and self-renewal potential G Guenechea, OI Gan, C Dorrell, JE Dick Nature immunology 2 (1), 75-82, 2001 | 393 | 2001 |
CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long-Term Culture-Initiating Cells, NOD/SCID-Repopulating Cells and Dendritic Cell … EA De Wynter, D Buck, C Hart, R Heywood, LH Coutinho, A Clayton, ... Stem Cells 16 (6), 387-396, 1998 | 326 | 1998 |
Transduction of human CD34+ CD38-bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors G Guenechea, OI Gan, T Inamitsu, C Dorrell, DS Pereira, M Kelly, ... Molecular Therapy 1 (6), 566-573, 2000 | 220 | 2000 |
Delayed Engraftment of Nonobese Diabetic/Severe Combined Immunodeficient Mice Transplanted With Ex Vivo–Expanded Human CD34+ Cord Blood Cells G Guenechea, JC Segovia, B Albella, M Lamana, M Ramırez, C Regidor, ... Blood, The Journal of the American Society of Hematology 93 (3), 1097-1105, 1999 | 179 | 1999 |
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia P Rio, S Navarro, W Wang, R Sanchez-Dominguez, RM Pujol, ... Nature medicine 25 (9), 1396-1401, 2019 | 140 | 2019 |
Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice J Barquinero, JC Segovia, M Ramırez, A Limón, G Güenechea, T Puig, ... Blood, The Journal of the American Society of Hematology 95 (10), 3085-3093, 2000 | 77 | 2000 |
Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients A Jacome, S Navarro, P Río, RM Yañez, A González-Murillo, ML Lozano, ... Molecular Therapy 17 (6), 1083-1092, 2009 | 71 | 2009 |
Efficient non-viral gene delivery into human hematopoietic stem cells by minicircle sleeping beauty transposon vectors M Holstein, C Mesa-Nuñez, C Miskey, E Almarza, V Poletti, M Schmeer, ... Molecular therapy 26 (4), 1137-1153, 2018 | 67 | 2018 |
A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells Á Raya, I Rodríguez-Pizà, S Navarro, Y Richaud-Patin, G Guenechea, ... nature protocols 5 (4), 647-660, 2010 | 66 | 2010 |
Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia A Gonzalez-Murillo, ML Lozano, L Alvarez, A Jacome, E Almarza, ... Human gene therapy 21 (5), 623-630, 2010 | 62 | 2010 |
Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients P Río, S Navarro, G Guenechea, R Sánchez-Domínguez, ML Lamana, ... Blood, The Journal of the American Society of Hematology 130 (13), 1535-1542, 2017 | 56 | 2017 |
Conversion of human fibroblasts into monocyte-like progenitor cells J Pulecio, E Nivet, I Sancho-Martinez, M Vitaloni, G Guenechea, Y Xia, ... Stem Cells 32 (11), 2923-2938, 2014 | 55 | 2014 |
Lentiviral vector integration sites in human NOD/SCID repopulating cells S Laufs, G Guenechea, A Gonzalez‐Murillo, K Zsuzsanna Nagy, ... The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2006 | 48 | 2006 |
In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1 P Río, NW Meza, Á González-Murillo, S Navarro, L Álvarez, J Surrallés, ... Blood, The Journal of the American Society of Hematology 112 (13), 4853-4861, 2008 | 42 | 2008 |
Ex vivo expansion of umbilical cord blood (UCB) CD34+ cells alters the expression and function of α4β1 and α5β1 integrins M Ramírez, JC Segovia, I Benet, C Arbona, G Güenechea, C Blaya, ... British journal of haematology 115 (1), 213-221, 2001 | 40 | 2001 |
Generation of a high number of healthy erythroid cells from gene-edited pyruvate kinase deficiency patient-specific induced pluripotent stem cells Z Garate, O Quintana-Bustamante, AM Crane, E Olivier, L Poirot, ... Stem Cell Reports 5 (6), 1053-1066, 2015 | 39 | 2015 |
Characteristics of lentiviral vectors harboring the proximal promoter of the vav proto-oncogene: a weak and efficient promoter for gene therapy E Almarza, P Río, NW Meza, M Aldea, X Agirre, G Guenechea, ... Molecular Therapy 15 (8), 1487-1494, 2007 | 37 | 2007 |
In Vivo Dynamics of Human Stem Cell Repopulation in NOD/SCID Mice JE Dick, G Guenechea, OI Gan, C Dorrell Annals of the New York Academy of Sciences 938 (1), 184-190, 2001 | 35 | 2001 |
DNA delivery to ‘ex vivo’human liver segments MJ Herrero, L Sabater, G Guenechea, L Sendra, AI Montilla, R Abargues, ... Gene therapy 19 (5), 504-512, 2012 | 33 | 2012 |