Mitochondrial DNA copy number in human disease: the more the better? R Filograna, M Mennuni, D Alsina, NG Larsson FEBS letters 595 (8), 976-1002, 2021 | 278 | 2021 |
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells I Russo, G Berti, N Plotegher, G Bernardo, R Filograna, L Bubacco, ... Journal of neuroinflammation 12, 1-13, 2015 | 128 | 2015 |
A phenotype-driven approach to generate mouse models with pathogenic mtDNA mutations causing mitochondrial disease JHK Kauppila, HL Baines, A Bratic, ML Simard, C Freyer, A Mourier, ... Cell reports 16 (11), 2980-2990, 2016 | 115 | 2016 |
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse R Filograna, C Koolmeister, M Upadhyay, A Pajak, P Clemente, R Wibom, ... Science Advances 5 (4), eaav9824, 2019 | 113 | 2019 |
The clinical use of the neutrophil to lymphocyte ratio (NLR) in urothelial cancer: a systematic review M Marchioni, G Primiceri, M Ingrosso, R Filograna, P Castellan, ... Clinical genitourinary cancer 14 (6), 473-484, 2016 | 107 | 2016 |
Anti-oxidants in Parkinson’s disease therapy: a critical point of view R Filograna, M Beltramini, L Bubacco, M Bisaglia Current Neuropharmacology 14 (3), 260-271, 2016 | 101 | 2016 |
Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease? M Bisaglia, R Filograna, M Beltramini, L Bubacco Ageing research reviews 13, 107-114, 2014 | 91 | 2014 |
Analysis of the catecholaminergic phenotype in human SH-SY5Y and BE (2)-M17 neuroblastoma cell lines upon differentiation R Filograna, L Civiero, V Ferrari, G Codolo, E Greggio, L Bubacco, ... PLoS one 10 (8), e0136769, 2015 | 87 | 2015 |
Superoxide dismutase (SOD)-mimetic M40403 is protective in cell and fly models of paraquat toxicity: implications for Parkinson disease R Filograna, VK Godena, A Sanchez-Martinez, E Ferrari, L Casella, ... Journal of Biological Chemistry 291 (17), 9257-9267, 2016 | 75 | 2016 |
Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo A Pajak, I Laine, P Clemente, N El-Fissi, FA Schober, C Maffezzini, ... PLoS genetics 15 (7), e1008240, 2019 | 51 | 2019 |
Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss A Biosa, A Sanchez-Martinez, R Filograna, A Terriente-Felix, SM Alam, ... Human molecular genetics 27 (9), 1618-1629, 2018 | 31 | 2018 |
The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters FA Rosenberger, D Moore, I Atanassov, MF Moedas, P Clemente, ... Science Advances 7 (8), eabf0717, 2021 | 26 | 2021 |
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen M Mennuni, R Filograna, A Felser, NA Bonekamp, P Giavalisco, ... EMBO reports 23 (1), e53054, 2022 | 21 | 2022 |
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes D Milenkovic, J Misic, JF Hevler, T Molinié, I Chung, I Atanassov, X Li, ... Cell Metabolism 35 (10), 1799-1813. e7, 2023 | 11 | 2023 |
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion J Misic, D Milenkovic, A Al-Behadili, X Xie, M Jiang, S Jiang, R Filograna, ... Nucleic Acids Research 50 (15), 8749-8766, 2022 | 10 | 2022 |
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response R Filograna, S Lee, K Tiklova, M Mennuni, V Jonsson, M Ringnér, ... PLoS Genetics 17 (9), e1009822, 2021 | 9 | 2021 |
Superoxide dismutases SOD1 and SOD2 rescue the toxic effect of dopamine-derived products in human SH-SY5Y neuroblastoma cells A Biosa, F De Lazzari, A Masato, R Filograna, N Plotegher, M Beltramini, ... Neurotoxicity Research 36, 746-755, 2019 | 5 | 2019 |
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA LS Kremer, LV Bozhilova, D Rubalcava-Gracia, R Filograna, M Upadhyay, ... PLoS Genetics 19 (1), e1010573, 2023 | 2 | 2023 |
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations J Zhang, C Koolmeister, J Han, R Filograna, L Hanke, M Àdori, ... JCI insight 8 (17), 2023 | 1 | 2023 |
Parkin is not required to sustain OXPHOS function in adult mammalian tissues R Filograna, J Gerlach, HN Choi, G Rigoni, M Barbaro, M Oscarson, ... bioRxiv, 2023.09. 02.556020, 2023 | 1 | 2023 |