Laura Perez-Benito
Laura Perez-Benito
Scientist Computational Chemistry Janssen
Verified email at e-campus.uab.cat
Title
Cited by
Cited by
Year
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G i and G s
G Navarro, A Cordomí, M Zelman-Femiak, M Brugarolas, E Moreno, ...
BMC biology 14 (1), 26, 2016
732016
Application of free energy perturbation for the design of BACE1 inhibitors
M Ciordia, L Pérez-Benito, F Delgado, AA Trabanco, G Tresadern
Journal of Chemical information and modeling 56 (9), 1856-1871, 2016
602016
Acylguanidine beta secretase 1 inhibitors: A combined experimental and free energy perturbation study
H Keränen, L Pérez-Benito, M Ciordia, F Delgado, TB Steinbrecher, ...
Journal of chemical theory and computation 13 (3), 1439-1453, 2017
372017
Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222
MLJ Doornbos, L Pérez‐Benito, G Tresadern, T Mulder‐Krieger, ...
British journal of pharmacology 173 (3), 588-600, 2016
262016
Cross-communication between G i and G s in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
G Navarro, A Cordomí, M Brugarolas, E Moreno, D Aguinaga, ...
BMC biology 16 (1), 24, 2018
252018
Molecular switches of allosteric modulation of the metabotropic glutamate 2 receptor
L Pérez-Benito, MLJ Doornbos, A Cordomí, L Peeters, H Lavreysen, ...
Structure 25 (7), 1153-1162. e4, 2017
222017
Predicting binding free energies of pde2 inhibitors. the difficulties of protein conformation
L Pérez-Benito, H Keränen, H van Vlijmen, G Tresadern
Scientific reports 8 (1), 1-10, 2018
192018
Gastrin-stimulated Gα13 activation of Rgnef protein (ArhGEF28) in DLD-1 colon carcinoma cells
M Masià-Balagué, I Izquierdo, G Garrido, A Cordomí, L Pérez-Benito, ...
Journal of Biological Chemistry 290 (24), 15197-15209, 2015
152015
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and …
JM Cid, G Tresadern, JA Vega, AI de Lucas, A del Cerro, E Matesanz, ...
Journal of medicinal chemistry 59 (18), 8495-8507, 2016
142016
Design of a true bivalent ligand with picomolar binding affinity for a G protein-coupled receptor homodimer
D Pulido, V Casadó-Anguera, L Pérez-Benito, E Moreno, A Cordomí, ...
Journal of medicinal chemistry 61 (20), 9335-9346, 2018
132018
Identification of allosteric modulators of metabotropic glutamate 7 receptor using proteochemometric modeling
G Tresadern, AA Trabanco, L Pérez-Benito, JP Overington, ...
Journal of chemical information and modeling 57 (12), 2976-2985, 2017
122017
Mechanisms underlying allosteric molecular switches of metabotropic glutamate receptor 5
C Llinas del Torrent, N Casajuana-Martin, L Pardo, G Tresadern, ...
Journal of chemical information and modeling 59 (5), 2456-2466, 2019
102019
Covalent allosteric probe for the metabotropic glutamate receptor 2: design, synthesis, and pharmacological characterization
MLJ Doornbos, X Wang, SC Vermond, L Peeters, L Pérez-Benito, ...
Journal of medicinal chemistry 62 (1), 223-233, 2018
102018
A Versatile Approach to CF3‐Containing 2‐Pyrrolidones by Tandem Michael Addition–Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 …
N Mateu, M Ciordia, O Delgado, M Sánchez‐Roselló, AA Trabanco, ...
Chemistry–A European Journal 21 (33), 11719-11726, 2015
102015
Predicting Activity Cliffs with Free-Energy Perturbation
L Pérez-Benito, N Casajuana-Martin, M Jiménez-Rosés, H van Vlijmen, ...
Journal of chemical theory and computation 15 (3), 1884-1895, 2019
92019
DeltaDelta neural networks for lead optimization of small molecule potency
J Jiménez-Luna, L Pérez-Benito, G Martínez-Rosell, S Sciabola, R Torella, ...
Chemical Science 10 (47), 10911-10918, 2019
52019
Computational drug design applied to the study of metabotropic glutamate receptors
C Llinas del Torrent, L Pérez-Benito, G Tresadern
Molecules 24 (6), 1098, 2019
52019
The size matters? A computational tool to design bivalent ligands
L Pérez-Benito, A Henry, MT Matsoukas, L Lopez, D Pulido, M Royo, ...
Bioinformatics, 2018
52018
Accuracy and Precision of Alchemical Relative Free Energy Predictions with and without Replica‐Exchange
S Wan, G Tresadern, L Pérez‐Benito, H van Vlijmen, PV Coveney
Advanced Theory and Simulations 3 (1), 1900195, 2020
22020
Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor
JM Cid, H Lavreysen, G Tresadern, L Pérez-Benito, F Tovar, A Fontana, ...
ACS chemical neuroscience 10 (3), 1043-1054, 2018
22018
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