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Alison Goate
Alison Goate
Professor of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai
Email confirmado em mssm.edu - Página inicial
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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
A Goate, MC Chartier-Harlin, M Mullan, J Brown, F Crawford, L Fidani, ...
Nature 349 (6311), 704-706, 1991
62641991
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
43032013
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
M Hutton, CL Lendon, P Rizzu, M Baker, S Froelich, H Houlden, ...
Nature 393 (6686), 702-705, 1998
42141998
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
RJ Bateman, C Xiong, TLS Benzinger, AM Fagan, A Goate, NC Fox, ...
New England Journal of Medicine 367 (9), 795-804, 2012
39452012
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
32752009
TREM2 variants in Alzheimer's disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
30392013
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ...
Nature 398 (6727), 518-522, 1999
27061999
Genome-wide association study reveals genetic risk underlying Parkinson's disease
J Simon-Sanchez, C Schulte, JM Bras, M Sharma, JR Gibbs, D Berg, ...
Nature genetics 41 (12), 1308-1312, 2009
21782009
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
21432011
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
21312019
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
21262011
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, ...
Nature genetics 46 (9), 989-993, 2014
19802014
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
MC Chartier-Harlin, F Crawford, H Houlden, A Warren, D Hughes, ...
Nature 353 (6347), 844-846, 1991
17511991
Alzheimer’s disease: the challenge of the second century
DM Holtzman, JC Morris, AM Goate
Science translational medicine 3 (77), 77sr1-77sr1, 2011
16672011
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
13732015
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance
JM Castellano, J Kim, FR Stewart, H Jiang, RB DeMattos, BW Patterson, ...
Science translational medicine 3 (89), 89ra57-89ra57, 2011
13712011
Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, V Anttila, B Bulik-Sullivan, HK Finucane, ...
Science 360 (6395), eaap8757, 2018
13472018
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
M Hong, V Zhukareva, V Vogelsberg-Ragaglia, Z Wszolek, L Reed, ...
Science 282 (5395), 1914-1917, 1998
11921998
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
JC Morris, CM Roe, C Xiong, AM Fagan, AM Goate, DM Holtzman, ...
Annals of neurology 67 (1), 122-131, 2010
9522010
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
SF Saccone, AL Hinrichs, NL Saccone, GA Chase, K Konvicka, ...
Human molecular genetics 16 (1), 36-49, 2007
9422007
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