TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma DF Choy, KM Hart, LA Borthwick, A Shikotra, DR Nagarkar, S Siddiqui, ... Science translational medicine 7 (301), 301ra129-301ra129, 2015 | 486 | 2015 |
Cytokine mediated tissue fibrosis LA Borthwick, TA Wynn, AJ Fisher Biochimica et biophysica acta (BBA)-molecular basis of disease 1832 (7 …, 2013 | 417 | 2013 |
The IL-1 cytokine family and its role in inflammation and fibrosis in the lung LA Borthwick Seminars in immunopathology 38, 517-534, 2016 | 300 | 2016 |
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis KM Vannella, TR Ramalingam, LA Borthwick, L Barron, KM Hart, ... Science translational medicine 8 (337), 337ra65-337ra65, 2016 | 192 | 2016 |
IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts MI Suwara, NJ Green, LA Borthwick, J Mann, KD Mayer-Barber, L Barron, ... Mucosal immunology 7 (3), 684-693, 2014 | 187 | 2014 |
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation LA Borthwick, SM Parker, KA Brougham, GE Johnson, MR Gorowiec, ... Thorax 64 (9), 770-777, 2009 | 163 | 2009 |
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis LA Borthwick, L Barron, KM Hart, KM Vannella, RW Thompson, S Oland, ... Mucosal immunology 9 (1), 38-55, 2016 | 150 | 2016 |
International consensus on the definition and classification of fibrosis of the knee joint NS Kalson, LA Borthwick, DA Mann, DJ Deehan, P Lewis, C Mann, ... The bone & joint journal 98 (11), 1479-1488, 2016 | 127 | 2016 |
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-β1-dependent mechanism MR Gorowiec, LA Borthwick, SM Parker, JA Kirby, GC Saretzki, AJ Fisher Free Radical Biology and Medicine 52 (6), 1024-1032, 2012 | 127 | 2012 |
Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis KM Vannella, L Barron, LA Borthwick, KN Kindrachuk, PB Narasimhan, ... PLoS pathogens 10 (9), e1004372, 2014 | 125 | 2014 |
Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β KM Hart, T Fabre, JC Sciurba, RL Gieseck III, LA Borthwick, KM Vannella, ... Science translational medicine 9 (396), eaal3694, 2017 | 123 | 2017 |
Fibrosis is a common outcome following total knee arthroplasty N Abdul, D Dixon, A Walker, J Horabin, N Smith, DJ Weir, NT Brewster, ... Scientific reports 5 (1), 16469, 2015 | 91 | 2015 |
A bioreactor technology for modeling fibrosis in human and rodent precision‐cut liver slices HL Paish, LH Reed, H Brown, MC Bryan, O Govaere, J Leslie, BS Barksby, ... Hepatology 70 (4), 1377-1391, 2019 | 86 | 2019 |
Inflammation and epithelial to mesenchymal transition in lung transplant recipients: role in dysregulated epithelial wound repair LA Borthwick, EI McIlroy, MR Gorowiec, M Brodlie, GE Johnson, C Ward, ... American Journal of Transplantation 10 (3), 498-509, 2010 | 86 | 2010 |
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation L Barron, AM Smith, KC El Kasmi, JE Qualls, X Huang, A Cheever, ... PloS one 8 (4), e61961, 2013 | 85 | 2013 |
Transforming Growth Factor-β1 (TGF-β1) Driven Epithelial to Mesenchymal Transition (EMT) is Accentuated by Tumour Necrosis Factor α (TNFα) via Crosstalk … LA Borthwick, A Gardner, A De Soyza, DA Mann, AJ Fisher Cancer microenvironment 5, 45-57, 2012 | 84 | 2012 |
Epigenetic reprogramming in liver fibrosis and cancer CL Wilson, DA Mann, LA Borthwick Advanced Drug Delivery Reviews 121, 124-132, 2017 | 82 | 2017 |
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis AE John, RH Graves, KT Pun, G Vitulli, EJ Forty, PF Mercer, JL Morrell, ... Nature Communications 11 (1), 4659, 2020 | 75 | 2020 |
The role of interleukin-1β as a predictive biomarker and potential therapeutic target during clinical ex vivo lung perfusion ASI Andreasson, LA Borthwick, C Gillespie, K Jiwa, J Scott, P Henderson, ... The Journal of Heart and Lung Transplantation 36 (9), 985-995, 2017 | 70 | 2017 |
Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion ASI Andreasson, DM Karamanou, CS Gillespie, F Özalp, T Butt, P Hill, ... European Journal of Cardio-Thoracic Surgery 51 (3), 577-586, 2017 | 67 | 2017 |