Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm PA Beer, F Delhommeau, JP LeCouédic, MA Dawson, E Chen, ... Blood, The Journal of the American Society of Hematology 115 (14), 2891-2900, 2010 | 339 | 2010 |
Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation S Elf, NS Abdelfattah, E Chen, J Perales-Patón, EA Rosen, A Ko, ... Cancer discovery 6 (4), 368-381, 2016 | 293 | 2016 |
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 RK Schneider, M Schenone, MV Ferreira, R Kramann, CE Joyce, ... Nature medicine 22 (3), 288-297, 2016 | 253 | 2016 |
Discovering language model behaviors with model-written evaluations E Perez, S Ringer, K Lukošiūtė, K Nguyen, E Chen, S Heiner, C Pettit, ... arXiv preprint arXiv:2212.09251, 2022 | 249 | 2022 |
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia J Li, D Spensberger, JS Ahn, S Anand, PA Beer, C Ghevaert, E Chen, ... Blood, The Journal of the American Society of Hematology 116 (9), 1528-1538, 2010 | 248 | 2010 |
Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling E Chen, PA Beer, AL Godfrey, CA Ortmann, J Li, AP Costa-Pereira, ... Cancer cell 18 (5), 524-535, 2010 | 214 | 2010 |
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms W Tapper, AV Jones, R Kralovics, AS Harutyunyan, K Zoi, W Leung, ... Nature communications 6 (1), 6691, 2015 | 195 | 2015 |
Janus Kinase Deregulation in Leukemia and Lymphoma E Chen, LM Staudt, AR Green Immunity 36 (4), 529-541, 2012 | 170 | 2012 |
The transcription factor encyclopedia D Yusuf, SL Butland, MI Swanson, E Bolotin, A Ticoll, WA Cheung, ... Genome biology 13, 1-25, 2012 | 141 | 2012 |
Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms E Chen, RK Schneider, LJ Breyfogle, EA Rosen, L Poveromo, S Elf, A Ko, ... Blood, The Journal of the American Society of Hematology 125 (2), 327-335, 2015 | 128 | 2015 |
Mouse models of myeloproliferative neoplasms: JAK of all grades J Li, DG Kent, E Chen, AR Green Disease models & mechanisms 4 (3), 311-317, 2011 | 128 | 2011 |
JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone AL Godfrey, E Chen, F Pagano, CA Ortmann, Y Silber, B Bellosillo, ... Blood, The Journal of the American Society of Hematology 120 (13), 2704-2707, 2012 | 127 | 2012 |
Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice A Khalyfa, D Bourbeau, E Chen, E Petroulakis, J Pan, S Xu, E Wang Journal of Biological Chemistry 276 (25), 22915-22922, 2001 | 127 | 2001 |
Rapid up-regulation of peptide elongation factor EF-1α protein levels is an immediate early event during oxidative stress-induced apoptosis E Chen, G Proestou, D Bourbeau, E Wang Experimental cell research 259 (1), 140-148, 2000 | 122 | 2000 |
Measuring progress on scalable oversight for large language models SR Bowman, J Hyun, E Perez, E Chen, C Pettit, S Heiner, K Lukošiūtė, ... arXiv preprint arXiv:2211.03540, 2022 | 107 | 2022 |
Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein E Chen, ND Salinas, Y Huang, F Ntumngia, MD Plasencia, ML Gross, ... Proceedings of the National Academy of Sciences 113 (22), 6277-6282, 2016 | 101 | 2016 |
Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN S Elf, NS Abdelfattah, AJ Baral, D Beeson, JF Rivera, A Ko, N Florescu, ... Blood, The Journal of the American Society of Hematology 131 (7), 782-786, 2018 | 95 | 2018 |
JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease J Li, DG Kent, AL Godfrey, H Manning, J Nangalia, A Aziz, E Chen, ... Blood, The Journal of the American Society of Hematology 123 (20), 3139-3151, 2014 | 91 | 2014 |
How does JAK2V617F contribute to the pathogenesis of myeloproliferative neoplasms? E Chen, A Mullally Hematology 2014, the American Society of Hematology Education Program Book …, 2014 | 74 | 2014 |
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML Z Tothova, AL Valton, RA Gorelov, M Vallurupalli, JM Krill-Burger, ... JCI insight 6 (3), e142149, 2021 | 73 | 2021 |