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Edgar E Boczek
Edgar E Boczek
Dewpoint Therapeutics
Verified email at dewpointx.com
Title
Cited by
Cited by
Year
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
D Mateju, TM Franzmann, A Patel, A Kopach, EE Boczek, S Maharana, ...
The EMBO journal 36 (12), 1669-1687, 2017
4212017
Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90
EE Boczek, LG Reefschläger, M Dehling, TJ Struller, E Häusler, A Seidl, ...
Proceedings of the National Academy of Sciences 112 (25), E3189-E3198, 2015
962015
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
862019
Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting
B Dreier, G Mikheeva, N Belousova, P Parizek, E Boczek, I Jelesarov, ...
Journal of molecular biology 405 (2), 410-426, 2011
612011
Features of the chaperone cellular network revealed through systematic interaction mapping
K Rizzolo, J Huen, A Kumar, S Phanse, J Vlasblom, Y Kakihara, ...
Cell reports 20 (11), 2735-2748, 2017
602017
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
EE Boczek, J Fürsch, ML Niedermeier, L Jawerth, M Jahnel, M Ruer-Gruß, ...
Elife 10, e69377, 2021
442021
Hsp90 dependence of a kinase is determined by its conformational landscape
Q Luo, EE Boczek, Q Wang, J Buchner, VRI Kaila
Scientific reports 7 (1), 43996, 2017
282017
Autophosphorylation activates c-Src kinase through global structural rearrangements
EE Boczek, Q Luo, M Dehling, M Röpke, SL Mader, A Seidl, VRI Kaila, ...
Journal of Biological Chemistry 294 (35), 13186-13197, 2019
202019
Phase changes in neurotransmission
EE Boczek, S Alberti
Science 361 (6402), 548-549, 2018
92018
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. bioRxiv. 2019; 721001
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
Google Scholar][CrossRef][Green Version], 0
8
One domain fits all: Using disordered regions to sequester misfolded proteins
EE Boczek, S Alberti
The Journal of cell biology 217 (4), 1173, 2018
72018
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. bioRxiv: 721001
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
42019
Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process
D Choudhary, L Mediani, MJ Avellaneda, S Bjarnason, S Alberti, ...
Journal of the American Chemical Society 145 (28), 15188-15196, 2023
22023
The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences
E Boczek, G Gaglia, M Olshina, S Sarraf
Cell Stress and Chaperones 24 (3), 481-492, 2019
22019
Methods of characterizing condensate-associated characteristics of compounds and uses thereof
BA Beutel, PJ Dandliker, SP Hale, MA Murcko, EE Boczek, M Mittasch, ...
US Patent 11,493,519, 2022
12022
Methods of identifying interactions of a compound and a condensate, or a component thereof, and uses thereof
DM Mitrea, M Mittasch, PJ Dandliker, BA Beutel, EE Boczek
US Patent App. 18/020,897, 2023
2023
Methods of characterizing condensate-associated characteristics of compounds and uses thereof
BA Beutel, PJ Dandliker, SP Hale, MA Murcko, EE Boczek, M Mittasch, ...
US Patent App. 17/960,702, 2023
2023
Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models
H Uechi, S Sridharan, J Nijssen, J Bilstein, JM Iglesias-Artola, S Kishigami, ...
bioRxiv, 721001, 2019
2019
Three complementary mechanisms of quality control ensure RNP granule functionality and dynamics.
D Mateju, E Boczek, J Wang, A Kopach, S Maharana, A Patel, HO Lee, ...
MOLECULAR BIOLOGY OF THE CELL 27, 2016
2016
The maturation of Src kinase by the molecular chaperone Hsp90 and its kinase specific cochaperone Cdc37
E Boczek
Technische Universität München, 2015
2015
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Articles 1–20