Chihiro Sato
Chihiro Sato
Assistant Professor of Neurology, Washington University School of Medicine
Email confirmado em wustl.edu
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AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow
Neuron 52 (5), 831-843, 2006
11392006
Notch signaling in the regulation of stem cell self-renewal and differentiation
J Liu, C Sato, M Cerletti, A Wagers
Current topics in developmental biology 92, 367-409, 2010
3152010
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
2482018
C-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl …
Y Morohashi, T Kan, Y Tominari, H Fuwa, Y Okamura, N Watanabe, ...
Journal of Biological Chemistry 281 (21), 14670-14676, 2006
2222006
Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines
C Sato, Y Morohashi, T Tomita, T Iwatsubo
Journal of Neuroscience 26 (46), 12081-12088, 2006
1652006
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the γ-secretase
C Sato, S Takagi, T Tomita, T Iwatsubo
Journal of Neuroscience 28 (24), 6264-6271, 2008
1472008
Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 1
N Watanabe, T Tomita, C Sato, T Kitamura, Y Morohashi, T Iwatsubo
Journal of Biological Chemistry 280 (51), 41967-41975, 2005
1252005
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
1052020
Presenilin: RIP and beyond
MR Hass, C Sato, R Kopan, G Zhao
Seminars in cell & developmental biology 20 (2), 201-210, 2009
872009
Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate
N Isoo, C Sato, H Miyashita, M Shinohara, N Takasugi, Y Morohashi, ...
Journal of Biological Chemistry 282 (17), 12388-12396, 2007
772007
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase
S Takagi, A Tominaga, C Sato, T Tomita, T Iwatsubo
Journal of Neuroscience 30 (47), 15943-15950, 2010
622010
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease
NR Barthélemy, K Horie, C Sato, RJ Bateman
Journal of Experimental Medicine 217 (11), 2020
592020
Tau phosphorylation rates measured by mass spectrometry differ in the intracellular brain vs. extracellular cerebrospinal fluid compartments and are differentially affected by …
NR Barthélemy, N Mallipeddi, P Moiseyev, C Sato, RJ Bateman
Frontiers in aging neuroscience 11, 121, 2019
512019
An overview of notch signaling in adult tissue renewal and maintenance
C Sato, G Zhao, XG Ilagan
Current Alzheimer Research 9 (2), 227-240, 2012
502012
Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification
NR Barthélemy, RJ Bateman, C Hirtz, P Marin, F Becher, C Sato, ...
Alzheimer's research & therapy 12 (1), 1-11, 2020
462020
SILK studies—capturing the turnover of proteins linked to neurodegenerative diseases
RW Paterson, A Gabelle, BP Lucey, NR Barthélemy, CA Leckey, C Hirtz, ...
Nature Reviews Neurology 15 (7), 419-427, 2019
242019
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice
C Sato, M Turkoz, JT Dearborn, DF Wozniak, R Kopan, MR Hass
PloS one 7 (10), e48180, 2012
222012
Tau hyperphosphorylation on T217 in cerebrospinal fluid is specifically associated to amyloid-β pathology
NR Barthélemy, RJ Bateman, P Marin, F Becher, C Sato, S Lehmann, ...
bioRxiv, 226977, 2017
102017
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
K Horie, NR Barthélemy, N Mallipeddi, Y Li, EE Franklin, RJ Perrin, ...
Acta neuropathologica communications 8 (1), 1-14, 2020
92020
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Y Xu, S Du, JA Marsh, K Horie, C Sato, A Ballabio, CM Karch, ...
Molecular psychiatry, 1-15, 2020
82020
O sistema não pode efectuar a operação agora. Tente novamente mais tarde.
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