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Chihiro Sato
Chihiro Sato
Assistant Professor of Neurology, Washington University School of Medicine
Email confirmado em wustl.edu
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AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow
Neuron 52 (5), 831-843, 2006
12022006
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
3462018
Notch signaling in the regulation of stem cell self-renewal and differentiation
J Liu, C Sato, M Cerletti, A Wagers
Current topics in developmental biology 92, 367-409, 2010
3422010
C-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT (N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl …
Y Morohashi, T Kan, Y Tominari, H Fuwa, Y Okamura, N Watanabe, ...
Journal of Biological Chemistry 281 (21), 14670-14676, 2006
2252006
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
1942020
Structure of the catalytic pore of γ-secretase probed by the accessibility of substituted cysteines
C Sato, Y Morohashi, T Tomita, T Iwatsubo
Journal of Neuroscience 26 (46), 12081-12088, 2006
1652006
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the γ-secretase
C Sato, S Takagi, T Tomita, T Iwatsubo
Journal of Neuroscience 28 (24), 6264-6271, 2008
1522008
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease
NR Barthélemy, K Horie, C Sato, RJ Bateman
Journal of Experimental Medicine 217 (11), 2020
1402020
Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 1
N Watanabe, T Tomita, C Sato, T Kitamura, Y Morohashi, T Iwatsubo
Journal of Biological Chemistry 280 (51), 41967-41975, 2005
1322005
Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification
NR Barthélemy, RJ Bateman, C Hirtz, P Marin, F Becher, C Sato, ...
Alzheimer's research & therapy 12 (1), 1-11, 2020
962020
Presenilin: RIP and beyond
MR Hass, C Sato, R Kopan, G Zhao
Seminars in cell & developmental biology 20 (2), 201-210, 2009
892009
Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate
N Isoo, C Sato, H Miyashita, M Shinohara, N Takasugi, Y Morohashi, ...
Journal of Biological Chemistry 282 (17), 12388-12396, 2007
792007
Tau phosphorylation rates measured by mass spectrometry differ in the intracellular brain vs. extracellular cerebrospinal fluid compartments and are differentially affected by …
NR Barthélemy, N Mallipeddi, P Moiseyev, C Sato, RJ Bateman
Frontiers in aging neuroscience 11, 121, 2019
732019
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase
S Takagi, A Tominaga, C Sato, T Tomita, T Iwatsubo
Journal of Neuroscience 30 (47), 15943-15950, 2010
632010
An overview of notch signaling in adult tissue renewal and maintenance
C Sato, G Zhao, XG Ilagan
Current Alzheimer Research 9 (2), 227-240, 2012
552012
SILK studies—capturing the turnover of proteins linked to neurodegenerative diseases
RW Paterson, A Gabelle, BP Lucey, NR Barthélemy, CA Leckey, C Hirtz, ...
Nature Reviews Neurology 15 (7), 419-427, 2019
322019
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Y Xu, S Du, JA Marsh, K Horie, C Sato, A Ballabio, CM Karch, ...
Molecular psychiatry, 1-15, 2020
282020
CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease
K Horie, NR Barthelemy, C Sato, RJ Bateman
Brain 144 (2), 515-527, 2021
272021
Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice
C Sato, M Turkoz, JT Dearborn, DF Wozniak, R Kopan, MR Hass
PloS one 7 (10), e48180, 2012
232012
Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain
K Horie, NR Barthélemy, N Mallipeddi, Y Li, EE Franklin, RJ Perrin, ...
Acta neuropathologica communications 8 (1), 1-14, 2020
162020
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