Norman Sachs
Norman Sachs
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Designer matrices for intestinal stem cell and organoid culture
N Gjorevski, N Sachs, A Manfrin, S Giger, ME Bragina, P Ordóñez-Morán, ...
Nature 539 (7630), 560-564, 2016
Sequential cancer mutations in cultured human intestinal stem cells
J Drost, RH Van Jaarsveld, B Ponsioen, C Zimberlin, R Van Boxtel, ...
Nature 521 (7550), 43-47, 2015
A living biobank of breast cancer organoids captures disease heterogeneity
N Sachs, J de Ligt, O Kopper, E Gogola, G Bounova, F Weeber, ...
Cell 172 (1-2), 373-386. e10, 2018
Identification of multipotent luminal progenitor cells in human prostate organoid cultures
WR Karthaus, PJ Iaquinta, J Drost, A Gracanin, R Van Boxtel, J Wongvipat, ...
Cell 159 (1), 163-175, 2014
Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids
KK Dijkstra, CM Cattaneo, F Weeber, M Chalabi, J van de Haar, ...
Cell 174 (6), 1586-1598. e12, 2018
Kidney failure in mice lacking the tetraspanin CD151
N Sachs, M Kreft, MA van den Bergh Weerman, AJ Beynon, TA Peters, ...
Journal of Cell Biology 175 (1), 33-39, 2006
Organoid cultures for the analysis of cancer phenotypes
N Sachs, H Clevers
Current opinion in genetics & development 24, 68-73, 2014
Long‐term expanding human airway organoids for disease modeling
N Sachs, A Papaspyropoulos, DD Zomer‐van Ommen, I Heo, L Böttinger, ...
The EMBO journal 38 (4), e100300, 2019
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon
N Sasaki, N Sachs, K Wiebrands, SIJ Ellenbroek, A Fumagalli, ...
Proceedings of the National Academy of Sciences 113 (37), E5399-E5407, 2016
Integrin α3β1 inhibits directional migration and wound re-epithelialization in the skin
C Margadant, K Raymond, M Kreft, N Sachs, H Janssen, A Sonnenberg
Journal of Cell Science 122 (2), 278-288, 2009
Modelling Cryptosporidium infection in human small intestinal and lung organoids
I Heo, D Dutta, DA Schaefer, N Iakobachvili, B Artegiani, N Sachs, ...
Nature microbiology 3 (7), 814-823, 2018
Cell–matrix adhesion of podocytes in physiology and disease
N Sachs, A Sonnenberg
Nature Reviews Nephrology 9 (4), 200, 2013
Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome
N Nicolaou, C Margadant, SH Kevelam, MR Lilien, MJS Oosterveld, ...
The Journal of clinical investigation 122 (12), 4375-4387, 2012
MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells
M Yañez-Mó, O Barreiro, P Gonzalo, A Batista, D Megías, L Genís, ...
Blood, The Journal of the American Society of Hematology 112 (8), 3217-3226, 2008
Differentiated human airway organoids to assess infectivity of emerging influenza virus
J Zhou, C Li, N Sachs, MC Chiu, BHY Wong, H Chu, VKM Poon, D Wang, ...
Proceedings of the National Academy of Sciences 115 (26), 6822-6827, 2018
On the biomechanics of stem cell niche formation in the gut–modelling growing organoids
P Buske, J Przybilla, M Loeffler, N Sachs, T Sato, H Clevers, J Galle
The FEBS journal 279 (18), 3475-3487, 2012
Blood pressure influences end-stage renal disease of Cd151 knockout mice
N Sachs, N Claessen, J Aten, M Kreft, GJD Teske, A Koeman, CJ Zuurbier, ...
The Journal of clinical investigation 122 (1), 348-358, 2012
EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin β4
E Frijns, N Sachs, M Kreft, K Wilhelmsen, A Sonnenberg
Journal of Biological Chemistry 285 (48), 37650-37662, 2010
Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels
N Sachs, Y Tsukamoto, P Kujala, PJ Peters, H Clevers
Development 144 (6), 1107-1112, 2017
Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells
N Sachs, P Secades, L van Hulst, M Kreft, JY Song, A Sonnenberg
Proceedings of the National Academy of Sciences 109 (52), 21468-21473, 2012
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