Eric S Fischer
Eric S Fischer
Associate Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
Email confirmado em crystal.harvard.edu
Título
Citado por
Citado por
Ano
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide
ES Fischer, K Böhm, JR Lydeard, H Yang, MB Stadler, S Cavadini, ...
Nature 512 (7512), 49-53, 2014
5172014
The molecular basis of CRL4 DDB2/CSA ubiquitin ligase architecture, targeting, and activation
ES Fischer, A Scrima, K Böhm, S Matsumoto, GM Lingaraju, M Faty, ...
Cell 147 (5), 1024-1039, 2011
3392011
Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
G Petzold, ES Fischer, NH Thomä
Nature 532 (7597), 127-130, 2016
2592016
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
CM Olson, B Jiang, MA Erb, Y Liang, ZM Doctor, Z Zhang, T Zhang, ...
Nature chemical biology 14 (2), 163-170, 2018
1992018
A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader
HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ...
Cell chemical biology 25 (1), 88-99. e6, 2018
1802018
Crystal structure of the human COP9 signalosome
GM Lingaraju, RD Bunker, S Cavadini, D Hess, U Hassiepen, M Renatus, ...
Nature 512 (7513), 161-165, 2014
1782014
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
1772018
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome
KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ...
Elife 7, e38430, 2018
1512018
Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
S Cavadini, ES Fischer, RD Bunker, A Potenza, GM Lingaraju, KN Goldie, ...
Nature 531 (7596), 598-603, 2016
1312016
Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance
W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ...
Cell 174 (2), 300-311. e11, 2018
1032018
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ...
Cell chemical biology 26 (2), 300-306. e9, 2019
992019
Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6
B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray
Angewandte Chemie International Edition 58 (19), 6321-6326, 2019
912019
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
eLife 8, e45457, 2019
872019
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4 CRBN ubiquitin ligase
J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ...
Nature communications 8 (1), 1-11, 2017
862017
Chemically induced degradation of anaplastic lymphoma kinase (ALK)
CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ...
Journal of medicinal chemistry 61 (9), 4249-4255, 2018
822018
Potent and selective covalent quinazoline inhibitors of KRAS G12C
M Zeng, J Lu, L Li, F Feru, C Quan, TW Gero, SB Ficarro, Y Xiong, ...
Cell chemical biology 24 (8), 1005-1016. e3, 2017
752017
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
A Scrima, ES Fischer, GM Lingaraju, K Böhm, S Cavadini, NH Thomä
FEBS letters 585 (18), 2818-2825, 2011
682011
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ...
Cell Chemical Biology 27 (1), 19-31. e6, 2020
622020
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
M Słabicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, ...
Nature 585 (7824), 293-297, 2020
542020
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer
D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ...
Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019
532019
O sistema não pode efectuar a operação agora. Tente novamente mais tarde.
Artigos 1–20