HaloTag: a novel protein labeling technology for cell imaging and protein analysis GV Los, LP Encell, MG McDougall, DD Hartzell, N Karassina, C Zimprich, ... ACS chemical biology 3 (6), 373-382, 2008 | 2380 | 2008 |
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate MP Hall, J Unch, BF Binkowski, MP Valley, BL Butler, MG Wood, P Otto, ... ACS chemical biology 7 (11), 1848-1857, 2012 | 1496 | 2012 |
NanoLuc complementation reporter optimized for accurate measurement of protein interactions in cells AS Dixon, MK Schwinn, MP Hall, K Zimmerman, P Otto, TH Lubben, ... ACS chemical biology 11 (2), 400-408, 2016 | 1061 | 2016 |
CRISPR-mediated tagging of endogenous proteins with a luminescent peptide MK Schwinn, T Machleidt, K Zimmerman, CT Eggers, AS Dixon, R Hurst, ... ACS chemical biology 13 (2), 467-474, 2018 | 298 | 2018 |
HaloTag7: a genetically engineered tag that enhances bacterial expression of soluble proteins and improves protein purification RF Ohana, LP Encell, K Zhao, D Simpson, MR Slater, M Urh, KV Wood Protein expression and purification 68 (1), 110-120, 2009 | 167 | 2009 |
Suppl 1: Development of a dehalogenase-based protein fusion tag capable of rapid, selective and covalent attachment to customizable ligands LP Encell, RF Ohana, K Zimmerman, P Otto, G Vidugiris, MG Wood, ... Current chemical genomics 6, 55, 2012 | 136 | 2012 |
Growth factor engineering by degenerate homoduplex gene family recombination WM Coco, LP Encell, WE Levinson, MJ Crist, AK Loomis, LL Licato, ... Nature biotechnology 20 (12), 1246-1250, 2002 | 132 | 2002 |
Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals Y Su, JR Walker, Y Park, TP Smith, LX Liu, MP Hall, L Labanieh, R Hurst, ... Nature methods 17 (8), 852-860, 2020 | 131 | 2020 |
A luminescent biosensor with increased dynamic range for intracellular cAMP BF Binkowski, BL Butler, PF Stecha, CT Eggers, P Otto, K Zimmerman, ... ACS chemical biology 6 (11), 1193-1197, 2011 | 124 | 2011 |
Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging MP Hall, CC Woodroofe, MG Wood, I Que, M van’t Root, Y Ridwan, C Shi, ... Nature communications 9 (1), 132, 2018 | 120 | 2018 |
Synthetic Oplophorus luciferases with enhanced light output LP Encell, KV Wood, MG Wood, M Hall, P Otto, G Vidugiris, K Zimmerman US Patent 8,557,970, 2013 | 101 | 2013 |
Improving enzymes for cancer gene therapy LP Encell, DM Landis, LA Loeb Nature biotechnology 17 (2), 143-147, 1999 | 94 | 1999 |
Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use B Binkowski, LP Encell, M Hall, MB Robers, MR Slater, KV Wood, ... US Patent 8,669,103, 2014 | 84 | 2014 |
HaloTag™ Interchangeable labeling technology for cell imaging and protein capture G Los, A Darzins, N Karassina, C Zimprich, R Learish, MG McDougall, ... Cell Notes 11, 2-6, 2005 | 80 | 2005 |
Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein … A Darzins, L Encell, D Klaubert, GV Los, M McDougall, KV Wood, ... US Patent 7,429,472, 2008 | 79 | 2008 |
Covalent tethering of functional groups to proteins and substrates therefor A Darzins, L Encell, GV Los, KV Wood, MG Wood, C Zimprich US Patent 7,425,436, 2008 | 78 | 2008 |
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate. ACS Chem Biol 7: 1848–1857 MP Hall, J Unch, BF Binkowski, MP Valley, BL Butler, MG Wood, P Otto, ... | 68 | 2012 |
Creating novel enzymes by applied molecular evolution A Skandalis, LP Encell, LA Loeb Chemistry & biology 4 (12), 889-898, 1997 | 60 | 1997 |
Engineering human DNA alkyltransferases for gene therapy using random sequence mutagenesis LP Encell, MM Coates, LA Loeb Cancer research 58 (5), 1013-1020, 1998 | 50 | 1998 |
Covalent tethering of functional groups to proteins and substrates therefor A Darzins, L Encell, T Johnson, D Klaubert, G Los, M McDougall, K Wood, ... US Patent App. 11/509,796, 2007 | 46 | 2007 |