| Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies H Jiang, X Zhang, X Chen, P Aramsangtienchai, Z Tong, H Lin Chemical reviews 118 (3), 919-988, 2018 | 386 | 2018 |
| Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16 X Zhang, VM Crowley, TG Wucherpfennig, MM Dix, BF Cravatt Nature chemical biology 15 (7), 737-746, 2019 | 318 | 2019 |
| An activity-guided map of electrophile-cysteine interactions in primary human T cells EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ... Cell 182 (4), 1009-1026. e29, 2020 | 219 | 2020 |
| HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2 J Cao, L Sun, P Aramsangtienchai, NA Spiegelman, X Zhang, W Huang, ... Proceedings of the National Academy of Sciences 116 (12), 5487-5492, 2019 | 145 | 2019 |
| Loss of sirtuin 1 alters the secretome of breast cancer cells by impairing lysosomal integrity A Latifkar, L Ling, A Hingorani, E Johansen, A Clement, X Zhang, ... Developmental cell 49 (3), 393-408. e7, 2019 | 123 | 2019 |
| DCAF11 supports targeted protein degradation by electrophilic proteolysis-targeting chimeras X Zhang, LM Luukkonen, CL Eissler, VM Crowley, Y Yamashita, ... Journal of the American Chemical Society 143 (13), 5141-5149, 2021 | 95 | 2021 |
| Identifying the functional contribution of the defatty-acylase activity of SIRT6 X Zhang, S Khan, H Jiang, MA Antonyak, X Chen, NA Spiegelman, ... Nature chemical biology 12 (8), 614-620, 2016 | 92 | 2016 |
| SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation X Zhang, NA Spiegelman, OD Nelson, H Jing, H Lin. eLife 6, e25158, 2017 | 89 | 2017 |
| SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a H Jing, X Zhang, SA Wisner, X Chen, NA Spiegelman, ME Linder, H Lin Elife 6, e32436, 2017 | 87 | 2017 |
| Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors B He, J Hu, X Zhang, H Lin Organic & biomolecular chemistry 12 (38), 7498-7502, 2014 | 82 | 2014 |
| NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle T Kosciuk, IR Price, X Zhang, C Zhu, KN Johnson, S Zhang, SL Halaby, ... Nature communications 11 (1), 1067, 2020 | 81 | 2020 |
| SIRT2 reverses 4-oxononanoyl lysine modification on histones J Jin, B He, X Zhang, H Lin, Y Wang Journal of the American Chemical Society 138 (38), 12304-12307, 2016 | 80 | 2016 |
| SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context Z Tong, Y Wang, X Zhang, DD Kim, S Sadhukhan, Q Hao, H Lin ACS chemical biology 11 (3), 742-747, 2016 | 67 | 2016 |
| Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia L Garnar-Wortzel, TR Bishop, S Kitamura, N Milosevich, JN Asiaban, ... ACS central science 7 (5), 815-830, 2021 | 52 | 2021 |
| Targeted protein degradation by electrophilic PROTACs that stereoselectively and site-specifically engage DCAF1 Y Tao, D Remillard, EV Vinogradova, M Yokoyama, S Banchenko, ... Journal of the American Chemical Society 144 (40), 18688-18699, 2022 | 49 | 2022 |
| A small‐molecule SIRT2 inhibitor that promotes K‐Ras4a lysine fatty‐acylation NA Spiegelman, JY Hong, J Hu, H Jing, M Wang, IR Price, J Cao, M Yang, ... ChemMedChem 14 (7), 744-748, 2019 | 46 | 2019 |
| Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity‐Dependent Inhibition, and On‐Target Anticancer Activities NA Spiegelman, IR Price, H Jing, M Wang, M Yang, J Cao, JY Hong, ... ChemMedChem 13 (18), 1890-1894, 2018 | 45 | 2018 |
| Terpenoids from Tripterygium wilfordii J Xu, J Lu, F Sun, H Zhu, L Wang, X Zhang, Z Ma Phytochemistry 72 (11-12), 1482-1487, 2011 | 44 | 2011 |
| Lysine fatty acylation promotes lysosomal targeting of TNF-α H Jiang, X Zhang, H Lin Scientific reports 6 (1), 24371, 2016 | 40 | 2016 |
| Comparative nucleotide-dependent interactome analysis reveals shared and differential properties of KRas4a and KRas4b X Zhang, J Cao, SP Miller, H Jing, H Lin ACS Central Science 4 (1), 71-80, 2018 | 33 | 2018 |
Hening LinHoward Hughes Medical Institute, Cornell UniversityVerified email at cornell.edu
