Nicholas Harmer
Nicholas Harmer
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Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery
TL Blundell, BL Sibanda, RW Montalv„o, S Brewerton, V Chelliah, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 361†…, 2006
The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity,
NJ Harmer, L Pellegrini, D Chirgadze, J Fernandez-Recio, TL Blundell
Biochemistry 43 (3), 629-640, 2004
Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region
J Cuccui, TS Milne, N Harmer, AJ George, SV Harding, RE Dean, ...
Infection and immunity 80 (3), 1209-1221, 2012
Insights into the role of heparan sulphate in fibroblast growth factor signalling
NJ Harmer
Biochemical Society Transactions 34 (3), 442-445, 2006
Determination of protein-ligand interactions using differential scanning fluorimetry
M Vivoli, HR Novak, JA Littlechild, NJ Harmer
JoVE (Journal of Visualized Experiments), e51809, 2014
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens
AC Schuh, NA Watkins, Q Nguyen, NJ Harmer, M Lin, JYA Prosper, ...
Blood, The Journal of the American Society of Hematology 99 (5), 1692-1698, 2002
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)–FGF receptor–heparin complex
NJ Harmer, LL Ilag, B Mulloy, L Pellegrini, CV Robinson, TL Blundell
Journal of molecular biology 339 (4), 821-834, 2004
Myosin‐5, kinesin‐1 and myosin‐17 cooperate in secretion of fungal chitin synthase
M Schuster, S Treitschke, S Kilaru, J Molloy, NJ Harmer, G Steinberg
The EMBO journal 31 (1), 214-227, 2012
Characterization of carboxylic acid reductases as enzymes in the toolbox for synthetic chemistry
W Finnigan, A Thomas, H Cromar, B Gough, R Snajdrova, JP Adams, ...
ChemCatChem 9 (6), 1005-1017, 2017
Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms
SJ Goodger, CJ Robinson, KJ Murphy, N Gasiunas, NJ Harmer, ...
Journal of Biological Chemistry 283 (19), 13001-13008, 2008
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2: 2: 1 FGF1∑ FGFR2c∑ heparin ternary complexes
CJ Robinson, NJ Harmer, SJ Goodger, TL Blundell, JT Gallagher
Journal of biological chemistry 280 (51), 42274-42282, 2005
The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation
A Butt, VA Higman, C Williams, MP Crump, CM Hemsley, N Harmer, ...
Biochemical Journal 459 (2), 333-344, 2014
Zoonoses under our noses
AR Cross, VM Baldwin, S Roy, AE Essex-Lopresti, JL Prior, NJ Harmer
Microbes and Infection 21 (1), 10-19, 2019
Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin
NJ Harmer, CJ Robinson, LE Adam, LL Ilag, CV Robinson, JT Gallagher, ...
Biochemical Journal 393 (3), 741-748, 2006
A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence
IH Norville, NJ Harmer, SV Harding, G Fischer, KE Keith, KA Brown, ...
Infection and immunity 79 (11), 4299-4307, 2011
Effect of Substance P in Staphylococcus aureus and Staphylococcus epidermidis Virulence: Implication for Skin Homeostasis
A N'Diaye, L Mijouin, M Hillion, S Diaz, Y Konto-Ghiorghi, G Percoco, ...
Frontiers in Microbiology 7, 506, 2016
Glycosylation of DsbA in Francisella tularensis subsp. tularensis
RM Thomas, SM Twine, KM Fulton, L Tessier, SLN Kilmury, W Ding, ...
Journal of bacteriology 193 (19), 5498-5509, 2011
Engineering a seven enzyme biotransformation using mathematical modelling and characterized enzyme parts
W Finnigan, R Cutlan, R Snajdrova, JP Adams, JA Littlechild, NJ Harmer
ChemCatChem 11 (15), 3474-3489, 2019
Pseudomonas aeruginosa expresses a functional human natriuretic peptide receptor ortholog: involvement in biofilm formation
T Rosay, A Bazire, S Diaz, T Clamens, AS Blier, L Mijouin, B Hoffmann, ...
MBio 6 (4), e01033-15, 2015
The structural biology of growth factor receptor activation
NJ Harmer, D Chirgadze, KH Kim, L Pellegrini, TL Blundell
Biophysical chemistry 100 (1-3), 545-553, 2002
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