| High-dose factor VIII inhibits factor VIII–specific memory B cells in hemophilia A with factor VIII inhibitors C Hausl, RU Ahmad, M Sasgary, CB Doering, P Lollar, G Richter, ... Blood 106 (10), 3415-3422, 2005 | 143 | 2005 |
| High level expression of recombinant porcine coagulation factor VIII CB Doering, JF Healey, ET Parker, RT Barrow, P Lollar Journal of Biological Chemistry 277 (41), 38345-38349, 2002 | 127 | 2002 |
| Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction PM Zakas, HC Brown, K Knight, SL Meeks, HT Spencer, EA Gaucher, ... Nature biotechnology 35 (1), 35-37, 2017 | 113 | 2017 |
| Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor W Deng, Y Xu, W Chen, DS Paul, AK Syed, MA Dragovich, X Liang, ... Nature communications 7 (1), 12863, 2016 | 107 | 2016 |
| Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens LM Ide, B Gangadharan, KY Chiang, CB Doering, HT Spencer Blood, The Journal of the American Society of Hematology 110 (8), 2855-2863, 2007 | 104 | 2007 |
| Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A CB Doering, G Denning, K Dooriss, B Gangadharan, JM Johnston, ... Molecular Therapy 17 (7), 1145-1154, 2009 | 90 | 2009 |
| Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion CB Doering, JF Healey, ET Parker, RT Barrow, P Lollar Journal of Biological Chemistry 279 (8), 6546-6552, 2004 | 86 | 2004 |
| Expression and characterization of recombinant murine factor VIII CB Doering, ET Parker, JF Healey, HN Craddock, RT Barrow, P Lollar Thrombosis and haemostasis 88 (09), 450-458, 2002 | 78 | 2002 |
| High-level expression of porcine factor VIII from genetically modified bone marrow–derived stem cells B Gangadharan, ET Parker, LM Ide, HT Spencer, CB Doering Blood 107 (10), 3859-3864, 2006 | 73 | 2006 |
| Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII HT Spencer, G Denning, RE Gautney, B Dropulic, AJ Roy, L Baranyi, ... Molecular therapy 19 (2), 302-309, 2011 | 72 | 2011 |
| Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity CB Doering, B Gangadharan, HZ Dukart, HT Spencer Molecular Therapy 15 (6), 1093-1099, 2007 | 71 | 2007 |
| Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines SS Raikar, LC Fleischer, R Moot, A Fedanov, NY Paik, KA Knight, ... Oncoimmunology 7 (3), e1407898, 2018 | 69 | 2018 |
| Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC CD Porada, C Sanada, CJ Kuo, E Colletti, W Mandeville, J Hasenau, ... Experimental hematology 39 (12), 1124-1135. e4, 2011 | 66 | 2011 |
| Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A KL Dooriss, G Denning, B Gangadharan, EH Javazon, DA McCarty, ... Human gene therapy 20 (5), 465-478, 2009 | 63 | 2009 |
| Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors C Wichmann, I Quagliano-Lo Coco, Ö Yildiz, L Chen-Wichmann, H Weber, ... Leukemia 29 (2), 279-289, 2015 | 55 | 2015 |
| Preclinical development of a hematopoietic stem and progenitor cell bioengineered factor VIII lentiviral vector gene therapy for hemophilia A CB Doering, G Denning, JE Shields, EJ Fine, ET Parker, A Srivastava, ... Human Gene Therapy 29 (10), 1183-1201, 2018 | 52 | 2018 |
| Target-cell-directed bioengineering approaches for gene therapy of hemophilia A HC Brown, PM Zakas, SN George, ET Parker, HT Spencer, CB Doering Molecular Therapy-Methods & Clinical Development 9, 57-69, 2018 | 50 | 2018 |
| Enhanced biosynthesis of coagulation factor VIII through diminished engagement of the unfolded protein response HC Brown, B Gangadharan, CB Doering Journal of Biological Chemistry 286 (27), 24451-24457, 2011 | 47 | 2011 |
| Functional aspects of factor VIII expression after transplantation of genetically‐modified hematopoietic stem cells for hemophilia A LM Ide, NN Iwakoshi, B Gangadharan, S Jobe, R Moot, D McCarty, ... The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2010 | 47 | 2010 |
| Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery HC Brown, JF Wright, S Zhou, AM Lytle, JE Shields, HT Spencer, ... Molecular therapy Methods & clinical development 1, 2014 | 44 | 2014 |
