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Jacob Househam
Jacob Househam
Genomics and Evolutionary Dynamics Team, Centre for Evolution and Cancer, The Institute for Cancer
Email confirmado em icr.ac.uk - Página inicial
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Evolutionary dynamics of neoantigens in growing tumors
E Lakatos, MJ Williams, RO Schenck, WCH Cross, J Househam, L Zapata, ...
Nature genetics 52 (10), 1057-1066, 2020
872020
Phenotypic plasticity and genetic control in colorectal cancer evolution
J Househam, T Heide, GD Cresswell, I Spiteri, C Kimberley, L Zapata, ...
Nature 611 (7937), 744-753, 2022
762022
The co-evolution of the genome and epigenome in colorectal cancer
T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, M Mossner, ...
Nature 611 (7937), 733-743, 2022
552022
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
C Gabbutt, RO Schenck, DJ Weisenberger, C Kimberley, A Berner, ...
Nature biotechnology 40 (5), 720-730, 2022
282022
Integrated quality control of allele-specific copy numbers, mutations and tumour purity from cancer whole genome sequencing assays
J Househam, R Bergamin, S Milite, N Calonaci, A Antonello, MJ Williams, ...
bioRxiv, 2021.02. 13.429885, 2022
9*2022
Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A
DP Hart, N Uzun, S Skelton, A Kakoschke, J Househam, DS Moss, ...
haematologica 104 (3), 599, 2019
82019
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
AJ Cornish, AJ Gruber, B Kinnersley, D Chubb, A Frangou, G Caravagna, ...
bioRxiv, 2022.11. 16.515599, 2022
42022
Phenotypic noise and plasticity in cancer evolution
FJH Whiting, J Househam, AM Baker, A Sottoriva, TA Graham
Trends in Cell Biology, 2023
32023
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinoma
M Barroux, J Househam, E Lakatos, T Ronel, AM Baker, H Salié, ...
Research Square, 2023
12023
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
I Tomlinson, A Cornish, A Gruber, R Houlston, A Sud, P Law, E Lakatos, ...
12022
Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data
T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, C Kimberley, ...
bioRxiv, 2021.07. 14.451265, 2021
12021
Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc
A Antonello, R Bergamin, N Calonaci, J Househam, S Milite, MJ Williams, ...
Genome Biology 25 (1), 1-40, 2024
2024
Large-scale, low-cost, and accurate measurement of cancer evolutionary dynamics from clinical patient samples
C Gabbutt, M Duran-Ferrer, H Grant, D Mallo, F Nadeu, J Househam, ...
Cancer Research 84 (6_Supplement), 4300-4300, 2024
2024
Profiling of copy number alterations using low-coverage whole-genome sequencing informs differential diagnosis and prognosis in primary cutaneous follicle center lymphoma
B Bátai, L Kiss, L Varga, Á Nagy, J Househam, AM Baker, T László, ...
Modern Pathology, 100465, 2024
2024
Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
E Lakatos, V Gunasri, L Zapata, J Househam, T Heide, N Trahearn, ...
bioRxiv, 2024.02. 12.579956, 2024
2024
Spatially resolving the dynamics of immunoediting in advanced colorectal cancer
V Gunasri, N Trahearn, E Lakatos, J Househam, T Heide, GD Cresswell, ...
JOURNAL OF PATHOLOGY 261, S29-S29, 2023
2023
Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome
C Gabbutt, M Duran-Ferrer, H Grant, D Mallo, F Nadeu, J Househam, ...
medRxiv, 2023.11. 10.23298336, 2023
2023
O44 Co-evolution of mismatch repair loss and the immune response in Lynch Syndrome
O Swinyard, AM Baker, K Monahan, M Jansen, C Gabbutt, C Kimberley, ...
Gut 72 (Suppl 2), A25-A26, 2023
2023
O47 Spatially resolving the dynamics of immune escape in advanced colorectal cancer
V Gunasri, E Lakatos, N Trahearn, L Cisneros, J Househam, T Heide, ...
Gut 72 (Suppl 2), A27-A27, 2023
2023
253e IMMUNE EDITING IN THE INVASIVE MARGIN AND NODE DEPOSITS OF COLORECTAL CANCER SELECTS FOR CELLULAR NEIGHBOURHOODS ENRICHED IN PDL1+ CANCER CELLS
V Gunasri, E Lakatos, N Trahearn, L Cisneros, J Househam, T Heide, ...
Gastroenterology 164 (6), S-1569, 2023
2023
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