Kerensa Broersen
Kerensa Broersen
Universiteit Twente, MIRA Instituut
Email confirmado em utwente.nl
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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
I Kuperstein, K Broersen, I Benilova, J Rozenski, W Jonckheere, ...
The EMBO journal 29 (19), 3408-3420, 2010
4962010
The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ...
The EMBO journal 31 (10), 2261-2274, 2012
4602012
Structural basis for increased toxicity of pathological aβ42: aβ40 ratios in Alzheimer disease
K Pauwels, TL Williams, KL Morris, W Jonckheere, A Vandersteen, ...
Journal of biological chemistry 287 (8), 5650-5660, 2012
2162012
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
K Broersen, F Rousseau, J Schymkowitz
Alzheimer's research & therapy 2 (4), 1-14, 2010
1442010
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease
K Broersen, W Jonckheere, J Rozenski, A Vandersteen, K Pauwels, ...
Protein Engineering, Design & Selection 24 (9), 743-750, 2011
1132011
Glycoforms of β‐lactoglobulin with improved thermostability and preserved structural packing
K Broersen, AGJ Voragen, RJ Hamer, HHJ De Jongh
Biotechnology and Bioengineering 86 (1), 78-87, 2004
1052004
Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation
L Zhou, N Brouwers, I Benilova, A Vandersteen, M Mercken, K Van Laere, ...
EMBO molecular medicine 3 (5), 291-302, 2011
1042011
Mechanism of arachidonic acid action on syntaxin–Munc18
E Connell, F Darios, K Broersen, N Gatsby, SY Peak‐Chew, C Rickman, ...
EMBO reports 8 (4), 414-419, 2007
912007
α-Synuclein adopts an α-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation
K Broersen, D van den Brink, G Fraser, M Goedert, B Davletov
Biochemistry 45 (51), 15610-15616, 2006
762006
Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease
E Hubin, NAJ Van Nuland, K Broersen, K Pauwels
Cellular and Molecular Life Sciences 71 (18), 3507-3521, 2014
722014
Do sulfhydryl groups affect aggregation and gelation properties of ovalbumin?
K Broersen, AMM Van Teeffelen, A Vries, AGJ Voragen, RJ Hamer, ...
Journal of agricultural and food chemistry 54 (14), 5166-5174, 2006
662006
A comparative analysis of the aggregation behavior of amyloid-β peptide variants
A Vandersteen, E Hubin, R Sarroukh, G De Baets, J Schymkowitz, ...
FEBS letters 586 (23), 4088-4093, 2012
622012
Glucosylation of β‐lactoglobulin lowers the heat capacity change of unfolding; a unique way to affect protein thermodynamics
AMM Van Teeffelen, K Broersen, HHJ de Jongh
Protein Science 14 (8), 2187-2194, 2005
562005
Mechanistic insights in glycation-induced protein aggregation
M Adrover, L Mariño, P Sanchis, K Pauwels, Y Kraan, P Lebrun, ...
Biomacromolecules 15 (9), 3449-3462, 2014
442014
Chemical processing as a tool to generate ovalbumin variants with changed stability
HA Kosters, K Broersen, J de Groot, JWFA Simons, P Wierenga, ...
Biotechnology and bioengineering 84 (1), 61-70, 2003
442003
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool
A Vandersteen, MF Masman, G De Baets, W Jonckheere, K Van der Werf, ...
Journal of biological chemistry 287 (44), 36732-36743, 2012
392012
Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins
M Teodorowicz, O Perdijk, I Verhoek, C Govers, HFJ Savelkoul, Y Tang, ...
PloS one 12 (3), e0173778, 2017
352017
Net charge affects morphology and visual properties of ovalbumin aggregates
M Weijers, K Broersen, PA Barneveld, MA Cohen Stuart, RJ Hamer, ...
Biomacromolecules 9 (11), 3165-3172, 2008
352008
α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants
A Siekierska, G De Baets, J Reumers, R Gallardo, S Rudyak, K Broersen, ...
Journal of Biological Chemistry 287 (34), 28386-28397, 2012
312012
α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants
A Siekierska, G De Baets, J Reumers, R Gallardo, S Rudyak, K Broersen, ...
Journal of Biological Chemistry 287 (34), 28386-28397, 2012
312012
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