Peter O. Bauer
Peter O. Bauer
Bioinova
Email confirmado em bioinova.cz
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C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
J Chew, TF Gendron, M Prudencio, H Sasaguri, YJ Zhang, ...
Science 348 (6239), 1151-1154, 2015
3382015
Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS
Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ...
Neuron 83 (5), 1043-1050, 2014
2872014
Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study
M van Blitterswijk, M DeJesus-Hernandez, E Niemantsverdriet, ...
The Lancet Neurology 12 (10), 978-988, 2013
2652013
Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood
VV Belzil, PO Bauer, M Prudencio, TF Gendron, CT Stetler, IK Yan, ...
Acta neuropathologica 126 (6), 895-905, 2013
2632013
The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
PO Bauer, N Nukina
Journal of neurochemistry 110 (6), 1737-1765, 2009
2182009
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
PO Bauer, A Goswami, HK Wong, M Okuno, M Kurosawa, M Yamada, ...
Nature biotechnology 28 (3), 256-263, 2010
1962010
Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism
HK Wong, PO Bauer, M Kurosawa, A Goswami, C Washizu, Y Machida, ...
Human molecular genetics 17 (20), 3223-3235, 2008
1332008
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells
H Doi, K Okamura, PO Bauer, Y Furukawa, H Shimizu, M Kurosawa, ...
Journal of Biological Chemistry 283 (10), 6489-6500, 2008
1332008
Inhibition of Rho kinases enhances the degradation of mutant huntingtin
PO Bauer, HK Wong, F Oyama, A Goswami, M Okuno, Y Kino, H Miyazaki, ...
Journal of Biological Chemistry 284 (19), 13153-13164, 2009
1132009
(Patho‐) physiological relevance of PINK 1‐dependent ubiquitin phosphorylation
FC Fiesel, M Ando, R Hudec, AR Hill, M Castanedes‐Casey, TR Caulfield, ...
EMBO reports 16 (9), 1114-1130, 2015
1012015
Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients
VV Belzil, PO Bauer, TF Gendron, ME Murray, D Dickson, L Petrucelli
Brain research 1584, 15-21, 2014
882014
Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency
WC Lee, S Almeida, M Prudencio, TR Caulfield, YJ Zhang, WM Tay, ...
Human molecular genetics 23 (6), 1467-1478, 2014
762014
Expanded polyglutamines impair synaptic transmission and ubiquitin–proteasome system in Caenorhabditis elegans
LA Khan, PO Bauer, H Miyazaki, KS Lindenberg, BG Landwehrmeyer, ...
Journal of neurochemistry 98 (2), 576-587, 2006
582006
Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications
JM Laffita-Mesa, PO Bauer, V Kourí, LP Serrano, J Roskams, DA Gotay, ...
Human genetics 131 (4), 625-638, 2012
492012
Chitin digestibility is dependent on feeding behaviors, which determine acidic chitinase mRNA levels in mammalian and poultry stomachs
E Tabata, A Kashimura, A Kikuchi, H Masuda, R Miyahara, Y Hiruma, ...
Scientific reports 8 (1), 1-11, 2018
452018
Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system
M Ohno, M Kimura, H Miyazaki, K Okawa, R Onuki, C Nemoto, E Tabata, ...
Scientific reports 6 (1), 1-9, 2016
412016
The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo
H Sasaguri, J Chew, YF Xu, TF Gendron, A Garrett, CW Lee, ...
Brain research 1647, 57-64, 2016
392016
Gliomagenesis arising from Pten-and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc
HS Kim, K Woolard, C Lai, PO Bauer, D Maric, H Song, A Li, S Kotliarova, ...
Cancer research 72 (22), 6065-6075, 2012
372012
Methylation of C9orf72 expansion reduces RNA foci formation and dipeptide-repeat proteins expression in cells
PO Bauer
Neuroscience letters 612, 204-209, 2016
362016
Enhanced degradation of mutant huntingtin by rho kinase inhibition is mediated through activation of proteasome and macroautophagy
PO Bauer, N Nukina
Autophagy 5 (5), 747-748, 2009
352009
O sistema não pode efectuar a operação agora. Tente novamente mais tarde.
Artigos 1–20