Rui M M Brito
Rui M M Brito
Associate Professor, Chemistry Department, University of Coimbra
Verified email at - Homepage
Cited by
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Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants
A Quintas, DC Vaz, I Cardoso, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 276 (29), 27207-27213, 2001
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine
RMM Brito, WLC Vaz
Analytical biochemistry 152 (2), 250-255, 1986
The tetrameric protein transthyretin dissociates to a non-native monomer in solution: a novel model for amyloidogenesis
A Quintas, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 274 (46), 32943-32949, 1999
The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution
A Quintas, MJM Saraiva, RMM Brito
Febs Letters 418 (3), 297-300, 1997
The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage
C Egas, N Lavoura, R Resende, RMM Brito, E Pires, MCP de Lima, ...
Journal of Biological Chemistry 275 (49), 38190-38196, 2000
Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I,
GMC Gasmi-Seabrook, JW Howarth, N Finley, E Abusamhadneh, ...
Biochemistry 38 (26), 8313-8322, 1999
Structural characterization of the minimal segment of TDP-43 competent for aggregation
M Mompeán, E Buratti, C Guarnaccia, RMM Brito, A Chakrabartty, ...
Archives of biochemistry and biophysics 545, 53-62, 2014
Mining approximate motifs in time series
PG Ferreira, PJ Azevedo, CG Silva, RMM Brito
International Conference on Discovery Science, 89-101, 2006
Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4
DC Vaz, JR Rodrigues, W Sebald, CM Dobson, RMM Brito
Protein science 15 (1), 33-44, 2006
Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin
VL Shnyrov, E Villar, GG Zhadan, JM Sanchez-Ruiz, A Quintas, ...
Biophysical chemistry 88 (1-3), 61-67, 2000
Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA
OA Chaves, CSH Jesus, PF Cruz, CMR Sant'Anna, RMM Brito, C Serpa
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 169, 175-181, 2016
The low-affinity Ca2 (+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction
HL Sweeney, RM Brito, PR Rosevear, JA Putkey
Proceedings of the National Academy of Sciences 87 (24), 9538-9542, 1990
Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding
GA Krudy, RMM Brito, JA Putkey, PR Rosevear
Biochemistry 31 (6), 1595-1602, 1992
Amyloid formation by transthyretin: from protein stability to protein aggregation
RMM Brito, AM Damas, MJ Saraiva
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 3 (4 …, 2003
Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel
CA Harley, CSH Jesus, R Carvalho, RMM Brito, JH Morais-Cabral
PLoS One 7 (3), e32654, 2012
Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system
V Carvalho, P Castanheira, TQ Faria, C Gonçalves, P Madureira, C Faro, ...
International journal of pharmaceutics 400 (1-2), 234-242, 2010
A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model
TQ Faria, ZL Almeida, PF Cruz, CSH Jesus, P Castanheira, RMM Brito
Physical Chemistry Chemical Physics 17 (11), 7255-7263, 2015
Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II
RMM Brito, JA Putkey, NCJ Strynadka, MNG James, PR Rosevear
Biochemistry 30 (42), 10236-10245, 1991
Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations
JR Rodrigues, CJV Simões, CG Silva, RMM Brito
Protein science 19 (2), 202-219, 2010
The apoptogenic toxin AIP56 is a metalloprotease AB toxin that cleaves NF-κb P65
DS Silva, LMG Pereira, AR Moreira, F Ferreira-da-Silva, RM Brito, ...
PLoS Pathog 9 (2), e1003128, 2013
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