| cAMP analog mapping of Epac1 and cAMP kinase: discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension AE Christensen, F Selheim, J de Rooij, S Dremier, F Schwede, KK Dao, ... Journal of Biological Chemistry 278 (37), 35394-35402, 2003 | 425 | 2003 |
| Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria. H Erlandsen, F Fusetti, A Martinez, E Hough, T Flatmark, RC Stevens Nature structural biology 4 (12), 995-1000, 1997 | 242 | 1997 |
| Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases … A Martinez, PM Knappskog, S Olafsdottir, AP Dřskeland, HG Eiken, ... Biochemical Journal 306 (2), 589-597, 1995 | 224 | 1995 |
| Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations H Erlandsen, AL Pey, A Gámez, B Pérez, LR Desviat, C Aguado, R Koch, ... Proceedings of the National Academy of Sciences 101 (48), 16903-16908, 2004 | 190 | 2004 |
| Predicted effects of missense mutations on native-state stability account for phenotypic outcome in phenylketonuria, a paradigm of misfolding diseases AL Pey, F Stricher, L Serrano, A Martinez The American Journal of Human Genetics 81 (5), 1006-1024, 2007 | 184 | 2007 |
| Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition KK Dao, K Teigen, R Kopperud, E Hodneland, F Schwede, ... Journal of Biological Chemistry 281 (30), 21500-21511, 2006 | 165 | 2006 |
| Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ... The Journal of clinical investigation 118 (8), 2858-2867, 2008 | 162 | 2008 |
| Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus. A Martínez, RL Olsen, JL Serra Comparative biochemistry and physiology. B, Comparative biochemistry 91 (4 …, 1988 | 146 | 1988 |
| Phenylalanine hydroxylase: function, structure, and regulation MI Flydal, A Martinez IUBMB life 65 (4), 341-349, 2013 | 139 | 2013 |
| Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations AL Pey, B Pérez, LR Desviat, MA Martínez, C Aguado, H Erlandsen, ... Human mutation 24 (5), 388-399, 2004 | 137 | 2004 |
| The 14-3-3 proteins in regulation of cellular metabolism R Kleppe, A Martinez, SO Dřskeland, J Haavik Seminars in cell & developmental biology 22 (7), 713-719, 2011 | 136 | 2011 |
| Recombinant human tyrosine hydroxylase isozymes: reconstitution with iron and inhibitory effect of other metal ions J HAAVIK, B LE BOURDELLES, A MARTINEZ, T FLATMARK, J MALLET European Journal of biochemistry 199 (2), 371-378, 1991 | 124 | 1991 |
| L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study M Thórólfsson, B Ibarra-Molero, P Fojan, SB Petersen, JM Sanchez-Ruiz, ... Biochemistry 41 (24), 7573-7585, 2002 | 114 | 2002 |
| Structure/function relationships in human phenylalanine hydroxylase: effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to … PM Knappskog, T Flatmark, JM Aarden, J Haavik, A Martínez European journal of biochemistry 242 (3), 813-821, 1996 | 114 | 1996 |
| Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit L Skjaerven, A Martinez, N Reuter Proteins: Structure, Function, and Bioinformatics 79 (1), 232-243, 2011 | 108 | 2011 |
| Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism JS Liberles, M Thórólfsson, A Martinez Amino acids 28 (1), 1-12, 2005 | 99 | 2005 |
| Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates … RH Schallreuter KU, Salem MA, Gibbons NC, Martinez A, Slominski R, Lüdemann J FASEB J. 26 (6), 2457-70, 2012 | 98* | 2012 |
| Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high … AE Fedřy, N Yang, A Martinez, HKS Leiros, IH Steen Journal of molecular biology 372 (1), 130-149, 2007 | 96 | 2007 |
| pH‐dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser‐40 J Haavik, A Martínez, T Fiatmark FEBS letters 262 (2), 363-365, 1990 | 92 | 1990 |
| Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability Y Anikster, TB Haack, T Vilboux, B Pode-Shakked, B Thöny, N Shen, ... The American Journal of Human Genetics 100 (2), 257-266, 2017 | 91 | 2017 |
Jan HaavikUniversity of BergenVerified email at biomed.uib.no
