| Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases D Rufino-Ramos, PR Albuquerque, V Carmona, R Perfeito, RJ Nobre, ... Journal of Controlled Release 262, 247-258, 2017 | 363 | 2017 |
| Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9 J Saraiva, RJ Nobre, LP de Almeida Journal of Controlled Release 241, 94-109, 2016 | 222 | 2016 |
| Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm RJ Nobre, LP de Almeida, TC Martins Journal of clinical virology 42 (1), 13-21, 2008 | 88 | 2008 |
| Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment I Onofre, N Mendonça, S Lopes, R Nobre, JB de Melo, IM Carreira, ... Scientific reports 6 (1), 28220, 2016 | 81 | 2016 |
| Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado–Joseph disease AT Simões, N Gonçalves, RJ Nobre, CB Duarte, L Pereira de Almeida Human molecular genetics 23 (18), 4932-4944, 2014 | 71 | 2014 |
| E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures RJ Nobre, E Herráez-Hernández, JW Fei, L Langbein, S Kaden, ... Journal of virology 83 (7), 2907-2916, 2009 | 62 | 2009 |
| Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders AC Silva, DD Lobo, IM Martins, SM Lopes, C Henriques, SP Duarte, ... Brain 143 (2), 407-429, 2020 | 58 | 2020 |
| Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death JT Costa, M Mele, MS Baptista, JR Gomes, K Ruscher, RJ Nobre, ... Molecular neurobiology 53, 3513-3527, 2016 | 41 | 2016 |
| Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5 AI Santos, BP Carreira, RJ Nobre, CM Carvalho, IM Araújo Stem cells international 2014, 2014 | 38 | 2014 |
| Simple and fast SEC-based protocol to isolate human plasma-derived extracellular vesicles for transcriptional research LS Gaspar, MM Santana, C Henriques, MM Pinto, TM Ribeiro-Rodrigues, ... Molecular Therapy-Methods & Clinical Development 18, 723-737, 2020 | 36 | 2020 |
| Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease CO Miranda, A Marcelo, TP Silva, J Barata, A Vasconcelos-Ferreira, ... Molecular Therapy 26 (9), 2131-2151, 2018 | 26 | 2018 |
| Gene therapy for Parkinson's and Alzheimer's diseases: from the bench to clinical trials R Jorge Nobre, L Pereira de Almeida Current pharmaceutical design 17 (31), 3434-3445, 2011 | 25 | 2011 |
| Gene therapies for polyglutamine diseases CA Matos, V Carmona, UG Vijayakumar, S Lopes, P Albuquerque, ... Polyglutamine Disorders, 395-438, 2018 | 24 | 2018 |
| Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line AP Marques, J Rosmaninho-Salgado, M Estrada, V Cortez, RJ Nobre, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1861 (3), 673-682, 2017 | 24 | 2017 |
| Trehalose alleviates the phenotype of Machado–Joseph disease mouse models MM Santana, S Paixão, J Cunha-Santos, TP Silva, A Trevino-Garcia, ... Journal of Translational Medicine 18, 1-17, 2020 | 22 | 2020 |
| Characterization of common and rare human papillomaviruses in Portuguese women by the polymerase chain reaction, restriction fragment length polymorphism and sequencing RJ Nobre, E Cruz, O Real, LP de Almeida, TC Martins Journal of medical virology 82 (6), 1024-1032, 2010 | 20 | 2010 |
| Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy A Marcelo, IT Afonso, R Afonso-Reis, DVC Brito, RG Costa, A Rosa, ... Cell Death & Disease 12 (12), 1117, 2021 | 18 | 2021 |
| The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples D Duarte Lobo, RJ Nobre, C Oliveira Miranda, D Pereira, J Castelhano, ... Acta Neuropathologica Communications 8, 1-19, 2020 | 17 | 2020 |
| Highly specific blood-brain barrier transmigrating single-domain antibodies selected by an in vivo phage display screening SI Aguiar, JNR Dias, AS André, ML Silva, D Martins, B Carrapiço, ... Pharmaceutics 13 (10), 1598, 2021 | 12 | 2021 |
| Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3 D Rufino-Ramos, PR Albuquerque, K Leandro, V Carmona, IM Martins, ... Molecular Therapy 31 (5), 1275-1292, 2023 | 9 | 2023 |
Luis Pereira de AlmeidaUniversity of Coimbra, CNC - Center for Neuroscience and Cell Biology & Faculty of Pharmacy & CIBBVerified email at cnc.uc.pt
