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Matthew Carter Childers
Matthew Carter Childers
University of Washington Department of Bioengineering
Verified email at uw.edu - Homepage
Title
Cited by
Cited by
Year
Insights from molecular dynamics simulations for computational protein design
MC Childers, V Daggett
Molecular systems design & engineering 2 (1), 9-33, 2017
2102017
α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease
D Shea, CC Hsu, TM Bi, N Paranjapye, MC Childers, J Cochran, ...
Proceedings of the National Academy of Sciences 116 (18), 8895-8900, 2019
1502019
Validating molecular dynamics simulations against experimental observables in light of underlying conformational ensembles
MC Childers, V Daggett
The Journal of Physical Chemistry B 122 (26), 6673-6689, 2018
842018
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ...
Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019
372019
The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design
MC Childers, CL Towse, V Daggett
Protein Engineering, Design and Selection 29 (7), 271-280, 2016
272016
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP
W Ma, M Childers, J Murray, F Moussavi‐Harami, H Gong, R Weiss, ...
The Journal of physiology 598 (22), 5165-5182, 2020
222020
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
W Ma, TS McMillen, MC Childers, H Gong, M Regnier, T Irving
Proceedings of the National Academy of Sciences 120 (5), e2207615120, 2023
192023
Edge strand dissociation and conformational changes in transthyretin under amyloidogenic conditions
MC Childers, V Daggett
Biophysical Journal 119 (10), 1995-2009, 2020
132020
Drivers of α-sheet formation in transthyretin under amyloidogenic conditions
MC Childers, V Daggett
Biochemistry 58 (44), 4408-4423, 2019
132019
Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts
M Landim-Vieira, MC Childers, AL Wacker, MR Garcia, H He, R Singh, ...
Elife 11, e74919, 2022
122022
Molecular dynamics-derived rotamer libraries for d-amino acids within homochiral and heterochiral polypeptides
MC Childers, CL Towse, V Daggett
Protein Engineering, Design and Selection 31 (6), 191-204, 2018
102018
Modulation of post-powerstroke dynamics in myosin II by 2′-deoxy-ADP
MC Childers, M Geeves, V Daggett, M Regnier
Archives of biochemistry and biophysics 699, 108733, 2021
72021
Conserved patterns and interactions in the unfolding transition state across SH3 domain structural homologues
C Demakis, MC Childers, V Daggett
Protein Science 30 (2), 391-407, 2021
62021
Molecular dynamics methods for antibody design
MC Childers, V Daggett
Computer-Aided Antibody Design, 109-124, 2022
42022
Insights from molecular dynamics simulations for computational protein design. Molecular Systems Design and Engineering, 2, 9–33
MC Childers, V Daggett
32017
Variants in ACTC1 underlie distal arthrogryposis accompanied by congenital heart defects
JX Chong, MC Childers, CT Marvin, AJ Marcello, H Gonorazky, ...
Human Genetics and Genomics Advances 4 (3), 2023
22023
Conformational sampling of CMT-2D associated GlyRS mutations
MC Childers, M Regnier, M Bothwell, AST Smith
Brain multiphysics 3, 100054, 2022
22022
Atomistic Simulations of Sarcomere Proteins
MC Childers, M Regnier
Familial Cardiomyopathies: Methods and Protocols, 27-41, 2023
12023
Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration
S Lee, AS Vander Roest, C Blair, K Kao, SB Bremner, MC Childers, ...
bioRxiv, 2023.06. 08.544276, 2023
12023
Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
MJ Rynkiewicz, MC Childers, OE Karpicheva, M Regnier, MA Geeves, ...
Journal of General Physiology 156 (5), e202413538, 2024
2024
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Articles 1–20