Leon J. De Windt
Leon J. De Windt
Professor of Molecular Cardiology at Maastricht University, The Netherlands
Email confirmado em maastrichtuniversity.nl
Citado por
Citado por
The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
OF Bueno, LJ De Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, ...
The EMBO journal 19 (23), 6341-6350, 2000
MiR423-5p as a circulating biomarker for heart failure
AJ Tijsen, EE Creemers, PD Moerland, LJ de Windt, AC van der Wal, ...
Circulation research 106 (6), 1035, 2010
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
T Taigen, LJ De Windt, HW Lim, JD Molkentin
Proceedings of the National Academy of Sciences 97 (3), 1196-1201, 2000
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo
Q Liang, LJ De Windt, SA Witt, TR Kimball, BE Markham, JD Molkentin
Journal of Biological Chemistry 276 (32), 30245-30253, 2001
Myocyte apoptosis in heart failure
VPM van Empel, ATA Bertrand, L Hofstra, HJ Crijns, PA Doevendans, ...
Cardiovascular research 67 (1), 21-29, 2005
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling
PA da Costa Martins, K Salic, MM Gladka, AS Armand, S Leptidis, ...
Nature cell biology 12 (12), 1220-1227, 2010
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression
U Delling, J Tureckova, HW Lim, LJ De Windt, P Rotwein, JD Molkentin
Molecular and cellular biology 20 (17), 6600-6611, 2000
Clinical perspective
PA da Costa Martins, M Bourajjaj, M Gladka, M Kortland, RJ van Oort, ...
Circulation 118 (15), 1567-1576, 2008
Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process
WA den Hengst, JF Gielis, JY Lin, PE Van Schil, LJ De Windt, AL Moens
American Journal of Physiology-Heart and Circulatory Physiology, 2010
Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth
BJ Wilkins, LJ De Windt, OF Bueno, JC Braz, BJ Glascock, TF Kimball, ...
Molecular and cellular biology 22 (21), 7603-7613, 2002
Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart: cross-talk between cardiac hypertrophic signaling pathways
LJ De Windt, HW Lim, S Haq, T Force, JD Molkentin
Journal of Biological Chemistry 275 (18), 13571-13579, 2000
Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure
LJ De Windt, HW Lim, T Taigen, D Wencker, G Condorelli, GW Dorn, ...
Circulation research 86 (3), 255-263, 2000
Long noncoding RNA Chast promotes cardiac remodeling
J Viereck, R Kumarswamy, A Foinquinos, K Xiao, P Avramopoulos, ...
Science translational medicine 8 (326), 326ra22-326ra22, 2016
Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo
LJ De Windt, HW Lim, OF Bueno, Q Liang, U Delling, JC Braz, ...
Proceedings of the National Academy of Sciences 98 (6), 3322-3327, 2001
Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy
R Roncarati, C Viviani Anselmi, MA Losi, L Papa, E Cavarretta, ...
Journal of the American College of Cardiology 63 (9), 920-927, 2014
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo
DJ Lips, OF Bueno, BJ Wilkins, NH Purcell, RA Kaiser, JN Lorenz, ...
Circulation 109 (16), 1938-1941, 2004
Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy
DJ Lips, LJ deWindt, DJW van Kraaij, PA Doevendans
European heart journal 24 (10), 883-896, 2003
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal–regulated kinase1/2 (ERK1/2)
JC Braz, OF Bueno, LJ De Windt, JD Molkentin
The Journal of cell biology 156 (5), 905-919, 2002
Estrogenic hormone action in the heart: regulatory network and function
FA Babiker, LJ De Windt, M van Eickels, C Grohe, R Meyer, ...
Cardiovascular Research 53 (3), 709-719, 2002
Regulation of fetal gene expression in heart failure
E Dirkx, PA da Costa Martins, LJ De Windt
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (12 …, 2013
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