Giampietro Schiavo
Giampietro Schiavo
UCL Queen Square Institute of Neurology
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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
G Schiavo, F Benfenati, B Poulain, O Rossetto, P Polverino de Laureto, ...
Nature 359, 1992
Neurotoxins affecting neuroexocytosis
G Schiavo, M Matteoli, C Montecucco
Physiological reviews 80 (2), 717-766, 2000
Mutations in dynein link motor neuron degeneration to defects in retrograde transport
M Hafezparast, R Klocke, C Ruhrberg, A Marquardt, A Ahmad-Annuar, ...
Science 300 (5620), 808-812, 2003
Mechanism of action of tetanus and botulinum neurotoxins
C Montecucco, G Schiavo
Molecular microbiology 13 (1), 1-8, 1994
Structure and function of tetanus and botulinum neurotoxins
C Montecucco, G Schiavo
Quarterly reviews of biophysics 28 (4), 423-472, 1995
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
G Schiavo, O Rossetto, S Catsicas, PP De Laureto, BR DasGupta, ...
Journal of biological chemistry 268 (32), 23784-23787, 1993
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
G Schiavo, A Santucci, BR Dasgupta, PP Mehta, J Jontes, F Benfenati, ...
FEBS letters 335 (1), 99-103, 1993
Activation of MDA5 requires higher-order RNA structures generated during virus infection
A Pichlmair, O Schulz, CP Tan, J Rehwinkel, H Kato, O Takeuchi, S Akira, ...
Journal of virology 83 (20), 10761-10769, 2009
Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway
K Deinhardt, S Salinas, C Verastegui, R Watson, D Worth, S Hanrahan, ...
Neuron 52 (2), 293-305, 2006
Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin
G Schiavo, CC Shone, O Rossetto, FC Alexander, C Montecucco
Journal of Biological Chemistry 268 (16), 11516-11519, 1993
Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin
G Schiavo, QM Gu, GD Prestwich, TH Söllner, JE Rothman
Proceedings of the National Academy of Sciences 93 (23), 13327-13332, 1996
Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
G Schiavo, G Stenbeck, JE Rothman, TH Söllner
Proceedings of the National Academy of Sciences 94 (3), 997-1001, 1997
Deficits in axonal transport precede ALS symptoms in vivo
LG Bilsland, E Sahai, G Kelly, M Golding, L Greensmith, G Schiavo
Proceedings of the National Academy of Sciences 107 (47), 20523-20528, 2010
Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.
G Schiavo, B Poulain, O Rossetto, F Benfenati, L Tauc, C Montecucco
The EMBO journal 11 (10), 3577-3583, 1992
Botulinum neurotoxins are zinc proteins.
G Schiavo, O Rossetto, A Santucci, BR DasGupta, C Montecucco
Journal of Biological Chemistry 267 (33), 23479-23483, 1992
Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins
G Schiavo, CC Shone, MK Bennett, RH Scheller, C Montecucco
Journal of biological chemistry 270 (18), 10566-10570, 1995
Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses
R Pellizzari, O Rossetto, G Schiavo, C Montecucco
Philosophical Transactions of the Royal Society of London. Series B …, 1999
Bacterial protein toxins penetrate cells via a four‐step mechanism
C Montecucco, E Papini, G Schiavo
FEBS letters 346 (1), 92-98, 1994
Tetanus and botulism neurotoxins: a new group of zinc proteases
C Montecucco, G Schiavo
Trends in biochemical sciences 18 (9), 324-327, 1993
A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice
D Kieran, M Hafezparast, S Bohnert, JRT Dick, J Martin, G Schiavo, ...
The Journal of cell biology 169 (4), 561-567, 2005
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