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Giuseppe Ronzitti
Giuseppe Ronzitti
INSERM Tenured researcher, Principal Investigator, Genethon
Email confirmado em genethon.fr
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Emerging issues in AAV-mediated in vivo gene therapy
P Colella, G Ronzitti, F Mingozzi
Molecular Therapy-Methods & Clinical Development 8, 87-104, 2018
7882018
Human immune responses to adeno-associated virus (AAV) vectors
G Ronzitti, DA Gross, F Mingozzi
Frontiers in immunology 11, 530953, 2020
2482020
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
C Leborgne, E Barbon, JM Alexander, H Hanby, S Delignat, DM Cohen, ...
Nature medicine 26 (7), 1096-1101, 2020
2182020
Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
A Meliani, F Boisgerault, R Hardet, S Marmier, F Collaud, G Ronzitti, ...
Nature communications 9 (1), 4098, 2018
2102018
The regulation of synaptic function by α-synuclein
S Bellani, VL Sousa, G Ronzitti, F Valtorta, J Meldolesi, E Chieregatti
Communicative & integrative biology 3 (2), 106-109, 2010
1702010
Influence of pre-existing anti-capsid neutralizing and binding antibodies on AAV vector transduction
Z Fitzpatrick, C Leborgne, E Barbon, E Masat, G Ronzitti, ...
Molecular therapy Methods & clinical development 9, 119-129, 2018
1552018
Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase
F Puzzo, P Colella, MG Biferi, D Bali, NK Paulk, P Vidal, F Collaud, ...
Science translational medicine 9 (418), eaam6375, 2017
1192017
TAAR1 modulates cortical glutamate NMDA receptor function
S Espinoza, G Lignani, L Caffino, S Maggi, I Sukhanov, D Leo, L Mus, ...
Neuropsychopharmacology 40 (9), 2217-2227, 2015
1182015
Enhanced liver gene transfer and evasion of preexisting humoral immunity with exosome-enveloped AAV vectors
A Meliani, F Boisgerault, Z Fitzpatrick, S Marmier, C Leborgne, F Collaud, ...
Blood advances 1 (23), 2019-2031, 2017
1052017
Selective disruption of the E-cadherin–catenin system by an algal toxin
G Ronzitti, F Callegari, C Malaguti, GP Rossini
British journal of cancer 90 (5), 1100-1107, 2004
952004
Exposure to wild-type AAV drives distinct capsid immunity profiles in humans
K Kuranda, P Jean-Alphonse, C Leborgne, R Hardet, F Collaud, ...
The Journal of clinical investigation 128 (12), 5267-5279, 2018
922018
A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line
M Bellocci, G Ronzitti, A Milandri, N Melchiorre, C Grillo, R Poletti, ...
Analytical Biochemistry 374 (1), 48-55, 2008
792008
GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein
S Bellani, A Mescola, G Ronzitti, H Tsushima, S Tilve, C Canale, ...
Cell Death & Differentiation 21 (12), 1971-1983, 2014
762014
Azaspiracid-1 alters the E-cadherin pool in epithelial cells
G Ronzitti, P Hess, N Rehmann, GP Rossini
Toxicological sciences 95 (2), 427-435, 2007
742007
Low-dose liver-targeted gene therapy for Pompe disease enhances therapeutic efficacy of ERT via immune tolerance induction
S Han, G Ronzitti, B Arnson, C Leborgne, S Li, F Mingozzi, D Koeberl
Molecular therapy Methods & clinical development 4, 126-136, 2017
712017
Exogenous α-synuclein decreases raft partitioning of Cav2. 2 channels inducing dopamine release
G Ronzitti, G Bucci, M Emanuele, D Leo, TD Sotnikova, LV Mus, ...
Journal of Neuroscience 34 (32), 10603-10615, 2014
662014
A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome
G Ronzitti, G Bortolussi, R Van Dijk, F Collaud, S Charles, C Leborgne, ...
Molecular therapy Methods & clinical development 3, 2016
652016
Preclinical development of an AAV8-hUGT1A1 vector for the treatment of Crigler-Najjar syndrome
F Collaud, G Bortolussi, L Guianvarc’h, SJ Aronson, T Bordet, P Veron, ...
Molecular Therapy-Methods & Clinical Development 12, 157-174, 2019
542019
SINEUP non-coding RNA targeting GDNF rescues motor deficits and neurodegeneration in a mouse model of Parkinson’s disease
S Espinoza, M Scarpato, D Damiani, F Managò, M Mereu, A Contestabile, ...
Molecular Therapy 28 (2), 642-652, 2020
522020
Parkin regulates kainate receptors by interacting with the GluK2 subunit
AM Maraschi, A Ciammola, A Folci, F Sassone, G Ronzitti, G Cappelletti, ...
Nature communications 5 (1), 5182, 2014
512014
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Artigos 1–20