Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome fibroblasts MU Bikkul, CS Clements, LS Godwin, MW Goldberg, IR Kill, JM Bridger Biogerontology 19, 579-602, 2018 | 46 | 2018 |
Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts … MU Bikkul, RGA Faragher, G Worthington, P Meinke, ARW Kerr, A Sammy, ... Genes, Chromosomes and Cancer 58 (6), 341-356, 2019 | 22 | 2019 |
Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways CS Clements, MU Bikkul, W Ofosu, C Eskiw, D Tree, E Makarov, IR Kill, ... Biogerontology 20, 337-358, 2019 | 21 | 2019 |
Interphase chromosome behavior in normal and diseased cells G Bourne, C Moir, U Bikkul, MH Ahmed, IR Kill, CH Eskiw, S Tosi, ... Human Interphase Chromosomes: Biomedical Aspects, 9-33, 2013 | 15 | 2013 |
Visualizing the Spatial Relationship of the Genome with the Nuclear Envelope Using Fluorescence In Situ Hybridization CS Clements, U Bikkul, MH Ahmed, HA Foster, LS Godwin, JM Bridger The Nuclear Envelope: Methods and Protocols, 387-406, 2016 | 10 | 2016 |
Telomere elongation through hTERT immortalisation leads to chromosome repositioning in control cells and genomic instability in HutchinsonGilford Progeria syndrome fibroblasts … JMB Mehmet U. Bikkul , Richard G.A. Faragher , Gemma Worthington , Peter ... Genes, Chromosomes and Cancer, 1-60, 2018 | | 2018 |
UNDERSTANDING AND TREATMENT OF HUTCHINSON-GILFORD PROGERIA SYNDROME, A MODEL FOR NORMAL AGING U Bikkul, G Bourne, C Clements, IR Kill, E Makarov, D Tree GERONTOLOGIST 56, 183-183, 2016 | | 2016 |
Using drug treatments to control genome behaviour in normal and Hutchinson-Gilford Progeria Syndrome fibroblasts, with and without hTERT immortalisation MU Bikkul Brunel University, 2016 | | 2016 |
Genome Organisation is affected in immortalised control and Hutchinson-Gilford Progeria Cells MU Bikkul, P Slijepcevic, R Anderson, RGA Faragher, IR Kill, JM Bridger Springer Verlag, 2015 | | 2015 |
Chromosome behaviour in hTERT normal and Huthcinson-Gilford Progeria Syndrome cells JB Mehmet Ural Bikkul, Gemma Bourne, Craig Clements, Christopher Eskiw ... 6th Nuclear Envelope Chromatin Organisation conference, 2013 | | 2013 |
Nuclear structure and genomic aberrations in hTERT immortalised Hutchinson-Gilford Progeria cells IRK Mehmet Ural Bikkul, Gemma Bourne, Christopher Eskiw, Evgeny M Makarov ... The EMBO, 2013 | | 2013 |
Severe Acute Respiratory Syndrome (SARS) MU Bikkul | | |
Visualizing the Spatial Relationship of the Genome withtheNuclearEnvelopeUsingFluorescenceInSitu Hybridization CS Clements, U Bikkul, MH Ahmed, HA Foster, LS Godwin, JM Bridger | | |
1 Centre for Cell & Chromosome Biology, 2 Brunel Institute for Cancer Genetics and Pharmacogenomics; Biosciences, School of Health Sciences and Social Care; Brunel; 3 Brighton … MU Bikkul, G Bourne, CH Eskiw, E Makarov, R Faragher, IR Kill, ... | | |
Treatment with a drug that inhibits telomerase restores aberrant chromosome 18 positioning in hTERT immortalised normal fibroblasts but not in hTERT immortalised atypical … MU Bikkul, P Slijepcevic, R Anderson, RGA Faragher, IR Kill, JM Bridger | | |