Leonard Amaral

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Miguel ViveirosProfessor of Microbiology, Inst. Higiene Medicina Tropical, Universidade NOVA de Lisboa, PortugalVerified email at ihmt.unl.pt
Isabel CoutoAssistant Professor of Medical Microbiology, IHMT, Universidade Nova de Lisboa, PortugalVerified email at ihmt.unl.pt
Diane OrdwayInfectious Disease, Colorado State UniversityVerified email at colostate.edu
Diana MachadoLaboratório de Micobacterias, Unidade de Microbiologia Médica, Instituto de Higiene e MedicinaVerified email at ihmt.unl.pt
Sofia Santos CostaGHTM, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, NOVAVerified email at ihmt.unl.pt
M L PascuINFLPR, ACADEMY OF ROMANIAN SCIENTISTS, ROMANIAN ACADEMY OF MEDICAL SCIENCESVerified email at inflpr.ro
Marcos A. P. Martins; Marcos Antonio...Universidade Federal de Santa MariaVerified email at pq.cnpq.br
Boni MihaiInstitutul National pentru Fizica Laserilor, Plasmei si RadiatieiVerified email at inflpr.ro
Maria José Umbelino FerreiraFaculty of Pharmacy, Universidade de Lisboa, Research Institute for Medicines (iMed.ULisboa)Verified email at ff.ulisboa.pt
Katarzyna Kieć-KononowiczProfesor, Uniwersytet JagiellońskiVerified email at uj.edu.pl
Cátia RamalheteProfessor of Pharmacology Science, Universidade AtlânticaVerified email at uatlantica.pt
Márió GajdácsUniversity of SzegedVerified email at stoma.szote.u-szeged.hu
João PerdigãoFaculty of Pharmacy - University of LisbonVerified email at ff.ul.pt
Andras SimonAssistant professorVerified email at mail.bme.hu
Stephen H. GillespieUniversity of St AndrewsVerified email at st-andrews.ac.uk
Adriana SmarandacheScientific researcher, National Institute for Laser, Plasma and Radiation Physics, RomaniaVerified email at inflpr.ro
Noton Kumar DuttaJohns Hopkins UniversityVerified email at jhmi.edu
Attila BalázsRichter GedeonVerified email at richter.hu
Alain MUSELLIPR Chimie, Université de CorseVerified email at univ-corse.fr
Pedro Viana Baptistai4HB & UCIBIO, Dept. Life Sciences, Faculdade Ciências e Tecnologia, Universidade Nova de LisboaVerified email at fct.unl.pt

Leonard Amaral

Professor Emeritus, Institute of Hygiene and Tropical Medicine of Lisbom

Verified email at ihmt.unl.pt

Infectious diseases Tuberculosis multi-drug resistance molecular biology drug development


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Multidrug efflux pumps in Staphylococcus aureus: an update SS Costa, M Viveiros, L Amaral, I Couto The open microbiology journal 7, 59, 2013	439	2013
Mechanisms of drug efflux and strategies to combat them: challenging the efflux pump of Gram-negative bacteria JM Pagès, L Amaral Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1794 (5), 826-833, 2009	402	2009
Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species V Lorenzi, A Muselli, AF Bernardini, L Berti, JM Pages, L Amaral, JM Bolla Antimicrobial agents and chemotherapy 53 (5), 2209-2211, 2009	344	2009
Antibiotic Stress, Genetic Response and Altered Permeability of E. coli M Viveiros, M Dupont, L Rodrigues, I Couto, A Davin-Regli, M Martins, ... PloS one 2 (4), e365, 2007	290	2007
Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis D Machado, I Couto, J Perdigao, L Rodrigues, I Portugal, P Baptista, ... PloS one 7 (4), e34538, 2012	289	2012
Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosis D Ordway, M Viveiros, C Leandro, R Bettencourt, J Almeida, M Martins, ... Antimicrobial agents and chemotherapy 47 (3), 917-922, 2003	271	2003
The potential management of resistant infections with non-antibiotics. JE Kristiansen, L Amaral The Journal of antimicrobial chemotherapy 40 (3), 319-327, 1997	244	1997
Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli L Paixão, L Rodrigues, I Couto, M Martins, P Fernandes, ... Journal of biological engineering 3, 1-13, 2009	215	2009
Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them L Amaral, A Martins, G Spengler, J Molnar Frontiers in pharmacology 4, 168, 2014	205	2014
Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities M Martins, SG Dastidar, S Fanning, JE Kristiansen, J Molnar, JM Pages, ... International journal of antimicrobial agents 31 (3), 198-208, 2008	202	2008
New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria G Spengler, A Kincses, M Gajdács, L Amaral Molecules 22 (3), 468, 2017	201	2017
Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of … L Amaral, JE Kristiansen, M Viveiros, J Atouguia Journal of Antimicrobial Chemotherapy 47 (5), 505-511, 2001	193	2001
Inhibition of quorum‐sensing signals by essential oils MÁ Szabó, GZ Varga, J Hohmann, Z Schelz, E Szegedi, L Amaral, ... Phytotherapy Research: An International Journal Devoted to Pharmacological …, 2010	187	2010
Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed … L Amaral, JE Kristiansen, LS Abebe, W Millett Journal of Antimicrobial Chemotherapy 38 (6), 1049-1053, 1996	186	1996
Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines M Viveiros, L Amaral International journal of antimicrobial agents 17 (3), 225-228, 2001	180	2001
Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method M Viveiros, A Martins, L Paixão, L Rodrigues, M Martins, I Couto, ... International journal of antimicrobial agents 31 (5), 458-462, 2008	178	2008
Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide I Couto, SS Costa, M Viveiros, M Martins, L Amaral Journal of antimicrobial chemotherapy 62 (3), 504-513, 2008	177	2008
Inducement and Reversal of Tetracycline Resistance in Escherichia coli K-12 and Expression of Proton Gradient-Dependent Multidrug Efflux Pump Genes M Viveiros, A Jesus, M Brito, C Leandro, M Martins, D Ordway, AM Molnar, ... Antimicrobial agents and chemotherapy 49 (8), 3578-3582, 2005	174	2005
Antimicrobial activity of phenothiazines L Amaral, M Viveiros, J Molnar in vivo 18 (6), 725-732, 2004	173	2004
Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex L Rodrigues, D Machado, I Couto, L Amaral, M Viveiros Infection, Genetics and Evolution 12 (4), 695-700, 2012	171	2012

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