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Gregory J Fonseca
Gregory J Fonseca
Email confirmado em mcgill.ca
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Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
D Gosselin, VM Link, CE Romanoski, GJ Fonseca, DZ Eichenfield, ...
Cell 159 (6), 1327-1340, 2014
12972014
Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes
P Pelka, JNG Ablack, GJ Fonseca, AF Yousef, JS Mymryk
Journal of virology 82 (15), 7252-7263, 2008
1892008
Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function
VM Link, SH Duttke, HB Chun, IR Holtman, E Westin, MA Hoeksema, ...
Cell 173 (7), 1796-1809. e17, 2018
1592018
Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification
GJ Fonseca, G Thillainadesan, AF Yousef, JN Ablack, KL Mossman, ...
Cell host & microbe 11 (6), 597-606, 2012
1392012
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
MA Lopez-Ramirez, G Fonseca, HA Zeineddine, R Girard, T Moore, ...
Journal of Experimental Medicine 214 (11), 3331-3346, 2017
942017
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages
GJ Fonseca, J Tao, EM Westin, SH Duttke, NJ Spann, T Strid, Z Shen, ...
Nature communications 10 (1), 414, 2019
602019
Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung
E Sajti, VM Link, Z Ouyang, NJ Spann, E Westin, CE Romanoski, ...
Nature immunology 21 (2), 221-231, 2020
562020
Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation
AF Yousef, GJ Fonseca, P Pelka, JNG Ablack, C Walsh, FA Dick, ...
Oncogene 29 (33), 4693-4704, 2010
462010
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes
J Koskimäki, R Girard, Y Li, L Saadat, HA Zeineddine, R Lightle, T Moore, ...
JCI insight 4 (3), 2019
442019
Identification of a second CtBP binding site in adenovirus type 5 E1A conserved region 3
RK Bruton, P Pelka, KL Mapp, GJ Fonseca, J Torchia, AS Turnell, ...
Journal of virology 82 (17), 8476-8486, 2008
402008
Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation
MJ Cohen, AF Yousef, P Massimi, GJ Fonseca, B Todorovic, P Pelka, ...
Journal of virology 87 (18), 10348-10355, 2013
372013
Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation
GJ Fonseca, MJ Cohen, AC Nichols, JW Barrett, JS Mymryk
PLoS pathogens 9 (6), e1003411, 2013
342013
TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy
S Bhattarai, Q Li, J Ding, F Liang, E Gusev, O Lapohos, GJ Fonseca, ...
Nature communications 13 (1), 879, 2022
302022
Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation
JNG Ablack, M Cohen, G Thillainadesan, GJ Fonseca, P Pelka, J Torchia, ...
Journal of virology 86 (15), 8198-8209, 2012
302012
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
J Koskimäki, D Zhang, Y Li, L Saadat, T Moore, R Lightle, SP Polster, ...
Acta Neuropathologica Communications 7, 1-15, 2019
282019
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19
J Ding, DE Hostallero, MR El Khili, GJ Fonseca, S Milette, N Noorah, ...
PLoS Computational Biology 17 (3), e1008810, 2021
242021
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19
N Aloufi, H Traboulsi, J Ding, GJ Fonseca, P Nair, SK Huang, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021
222021
Differential effects of human adenovirus E1A protein isoforms on aerobic glycolysis in A549 human lung epithelial cells
MA Prusinkiewicz, J Tu, MJ Dodge, KM MacNeil, S Radko-Juettner, ...
Viruses 12 (6), 610, 2020
212020
Adenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation
GJ Fonseca, MJ Cohen, JS Mymryk
Journal of virology 88 (10), 5630-5637, 2014
212014
Functional and structural mimicry of cellular protein kinase A anchoring proteins by a viral oncoprotein
CR King, MJ Cohen, GJ Fonseca, BS Dirk, JD Dikeakos, JS Mymryk
PLoS pathogens 12 (5), e1005621, 2016
192016
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