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Hirdesh Kumar
Hirdesh Kumar
Product Quality Reviewer @ FDA
Verified email at fda.hhs.gov - Homepage
Title
Cited by
Cited by
Year
Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance
AJ Gasparrini, JL Markley, H Kumar, B Wang, L Fang, S Irum, CT Symister, ...
Communications biology 3 (1), 241, 2020
1302020
Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis
AK Padhi, H Kumar, SV Vasaikar, B Jayaram, J Gomes
PLoS One 7 (2), e32479, 2012
632012
A unique profilin-actin interface is important for malaria parasite motility
CA Moreau, SP Bhargav, H Kumar, KA Quadt, H Piirainen, L Strauss, ...
PLoS pathogens 13 (5), e1006412, 2017
522017
Getting in: The structural biology of malaria invasion
H Kumar, NH Tolia
PLoS Pathogens 15 (9), e1007943, 2019
472019
Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments
RG Douglas, P Nandekar, JE Aktories, H Kumar, R Weber, JM Sattler, ...
PLoS biology 16 (7), e2005345, 2018
412018
Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors
H Kumar, A Shah, ME Sobhia
Journal of molecular modeling 18, 1791-1799, 2012
362012
Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts
JM Santos, S Egarter, V Zuzarte-Luis, H Kumar, CA Moreau, J Kehrer, ...
Elife 6, e24109, 2017
332017
Structure-and ligand-based drug design: concepts, approaches, and challenges
V Sharma, S Wakode, H Kumar
Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences, 27-53, 2021
302021
Semisynthetic analogues of anhydrotetracycline as inhibitors of tetracycline destructase enzymes
JL Markley, L Fang, AJ Gasparrini, CT Symister, H Kumar, NH Tolia, ...
ACS infectious diseases 5 (4), 618-633, 2019
302019
Protective efficacy and safety of liver stage attenuated malaria parasites
H Kumar, JM Sattler, M Singer, K Heiss, M Reinig, ...
Scientific Reports 6 (1), 26824, 2016
272016
Pharmacophore generation and atom based 3D-QSAR of quinoline derivatives as selective phosphodiesterase 4B inhibitors
V Sharma, H Kumar, S Wakode
RSC advances 6 (79), 75805-75819, 2016
252016
In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage
H Kumar, F Frischknecht, GR Mair, J Gomes
Infection, Genetics and Evolution 36, 72-81, 2015
192015
Insights into the Structural Requirements of PKCβII Inhibitors Based on HQSAR and CoMSIA Analyses
H Kumar, R Kumar, BK Grewal, ME Sobhia
Chemical Biology & Drug Design 78 (2), 283-288, 2011
172011
A function of profilin in force generation during malaria parasite motility that is independent of actin binding
CA Moreau, KA Quadt, H Piirainen, H Kumar, SP Bhargav, L Strauss, ...
Journal of cell science 134 (5), jcs233775, 2021
162021
Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and …
H Kumar, J Kehrer, M Singer, M Reinig, JM Santos, GR Mair, ...
Expert Opinion on Therapeutic Targets 23 (3), 251-261, 2019
82019
Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration
H Kumar, JR Jimah, SA Misal, ND Salinas, M Fried, PH Schlesinger, ...
Journal of Biological Chemistry 298 (9), 2022
52022
Structure of anhydrotetracycline-bound Tet (X6) reveals the mechanism for inhibition of type 1 tetracycline destructases
H Kumar, EE Williford, KS Blake, B Virgin-Downey, G Dantas, ...
Communications Biology 6 (1), 423, 2023
42023
Structure-based design of bisubstrate tetracycline destructase inhibitors that block flavin redox cycling
EE Williford, CM DeAngelo, KS Blake, H Kumar, KK Lam, KV Jones, ...
Journal of Medicinal Chemistry 66 (6), 3917-3933, 2023
32023
Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes
KS Blake, H Kumar, A Loganathan, EE Williford, L Diorio-Toth, YP Xue, ...
Communications Biology 7 (1), 336, 2024
12024
COMPOSITIONS COMPRISING CelTOS IMMUNOGENS AND ANTIBODIES AND METHOD OF USE THEREOF
N Tolia, J Jimah, N Salinas, D Urusova, J Adams, S Xu, A Roth, H Kumar
US Patent App. 16/346,811, 2019
12019
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Articles 1–20