| Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates MM Sousa, I Cardoso, R Fernandes, A Guimaraes, MJ Saraiva The American journal of pathology 159 (6), 1993-2000, 2001 | 415 | 2001 |
| Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants A Quintas, DC Vaz, I Cardoso, MJM Saraiva, RMM Brito Journal of Biological Chemistry 276 (29), 27207-27213, 2001 | 404 | 2001 |
| Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models I Cardoso, D Martins, T Ribeiro, G Merlini, MJ Saraiva Journal of translational medicine 8, 1-11, 2010 | 197 | 2010 |
| Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model I Cardoso, MJ Saraiva The FASEB Journal 20 (2), 234-239, 2006 | 184 | 2006 |
| Transthyretin binding to A-Beta peptide–impact on A-Beta fibrillogenesis and toxicity R Costa, A Gonçalves, MJ Saraiva, I Cardoso FEBS letters 582 (6), 936-942, 2008 | 177 | 2008 |
| Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity N Ferreira, I Cardoso, MR Domingues, R Vitorino, M Bastos, G Bai, ... FEBS letters 583 (22), 3569-3576, 2009 | 159 | 2009 |
| 4′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters I Cardoso, G Merlini, MJ Saraiva The FASEB journal 17 (8), 803-809, 2003 | 154 | 2003 |
| Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor R Costa, F Ferreira-da-Silva, MJ Saraiva, I Cardoso PloS one 3 (8), e2899, 2008 | 144 | 2008 |
| Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils I Cardoso, CS Goldsbury, SA Müller, V Olivieri, S Wirtz, AM Damas, ... Journal of molecular biology 317 (5), 683-695, 2002 | 144 | 2002 |
| Transthyretin and Alzheimer's disease: where in the brain? JC Sousa, I Cardoso, F Marques, MJ Saraiva, JA Palha Neurobiology of aging 28 (5), 713-718, 2007 | 142 | 2007 |
| Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative MR Almeida, B Macedo, I Cardoso, I Alves, G Valencia, G Arsequell, ... Biochemical Journal 381 (2), 351-356, 2004 | 115 | 2004 |
| Transthyretin participates in beta-amyloid transport from the brain to the liver-involvement of the low-density lipoprotein receptor-related protein 1? M Alemi, C Gaiteiro, CA Ribeiro, LM Santos, JR Gomes, SM Oliveira, ... Scientific reports 6 (1), 20164, 2016 | 95 | 2016 |
| Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease R Costa, E Speretta, DC Crowther, I Cardoso Journal of Biological Chemistry 286 (48), 41647-41655, 2011 | 88 | 2011 |
| Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses MR Almeida, L Gales, AM Damas, I Cardoso, MJ Saraiva Current Drug Targets-CNS & Neurological Disorders 4 (5), 587-596, 2005 | 83 | 2005 |
| Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)? SS Leal, I Cardoso, JS Valentine, CM Gomes Journal of Biological Chemistry 288 (35), 25219-25228, 2013 | 71 | 2013 |
| 4′-Iodo-4′-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid JA Palha, D Ballinari, N Amboldi, I Cardoso, R Fernandes, V Bellotti, ... The American journal of pathology 156 (6), 1919-1925, 2000 | 71 | 2000 |
| Dual ligand immunoliposomes for drug delivery to the brain JA Loureiro, B Gomes, G Fricker, I Cardoso, CA Ribeiro, C Gaiteiro, ... Colloids and Surfaces B: Biointerfaces 134, 213-219, 2015 | 66 | 2015 |
| The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation JS Cristóvão, VK Morris, I Cardoso, SS Leal, J Martínez, HM Botelho, ... Science advances 4 (6), eaaq1702, 2018 | 65 | 2018 |
| Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy FA Monteiro, MM Sousa, I Cardoso, JB do Amaral, A Guimarães, ... Journal of neurochemistry 97 (1), 151-161, 2006 | 64 | 2006 |
| Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation C A Ribeiro, I Santana, C Oliveira, I Baldeiras, J Moreira, M Joao Saraiva, ... Current Alzheimer Research 9 (8), 881-889, 2012 | 60 | 2012 |
