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Laura Gasparini
Laura Gasparini
Abbvie Deutschland GmbH & Co KG
Email confirmado em abbvie.com
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Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling
L Gasparini, GK Gouras, R Wang, RS Gross, MF Beal, P Greengard, H Xu
Journal of Neuroscience 21 (8), 2561-2570, 2001
6342001
Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
Y Chen, K Zhou, R Wang, Y Liu, YD Kwak, T Ma, RC Thompson, Y Zhao, ...
Proceedings of the National Academy of Sciences 106 (10), 3907-3912, 2009
4662009
Does insulin dysfunction play a role in Alzheimer's disease?
L Gasparini, WJ Netzer, P Greengard, H Xu
Trends in pharmacological sciences 23 (6), 288-293, 2002
4332002
Potential roles of insulin and IGF-1 in Alzheimer's disease
L Gasparini, H Xu
Trends in neurosciences 26 (8), 404-406, 2003
3642003
Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action
L Gasparini, E Ongini, G Wenk
Journal of neurochemistry 91 (3), 521-536, 2004
3062004
Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ EVIDENCE FOR DISTINCT MECHANISMS INVOLVED IN γ-SECRETASE PROCESSING OF THE APP …
C Yu, SH Kim, T Ikeuchi, H Xu, L Gasparini, R Wang, SS Sisodia
Journal of Biological Chemistry 276 (47), 43756-43760, 2001
2782001
Interaction of tau protein with the dynactin complex
E Magnani, J Fan, L Gasparini, M Golding, M Williams, G Schiavo, ...
The EMBO journal 26 (21), 4546-4554, 2007
2222007
Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome
A Contestabile, F Benfenati, L Gasparini
Progress in neurobiology 91 (1), 1-22, 2010
2112010
Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease
L Gasparini, M Racchi, G Binetti, M Trabucchi, SB Solerte, D Alkon, ...
The FASEB journal 12 (1), 17-34, 1998
1981998
Lithium rescues synaptic plasticity and memory in Down syndrome mice
A Contestabile, B Greco, D Ghezzi, V Tucci, F Benfenati, L Gasparini
The Journal of Clinical Investigation 123 (1), 348, 2013
1812013
A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
E Giorgio, D Robyr, M Spielmann, E Ferrero, E Di Gregorio, D Imperiale, ...
Human molecular genetics 24 (11), 3143-3154, 2015
1562015
Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features
V Tucci, T Kleefstra, A Hardy, I Heise, S Maggi, MH Willemsen, H Hilton, ...
The Journal of clinical investigation 124 (4), 1468, 2014
1522014
Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell cultures
L Gasparini, L Rusconi, H Xu, P Del Soldato, E Ongini
Journal of neurochemistry 88 (2), 337-348, 2004
1432004
Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability
L Gasparini, RA Crowther, KR Martin, N Berg, M Coleman, M Goedert, ...
Neurobiology of aging 32 (3), 419-433, 2011
1302011
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
E Barini, O Antico, Y Zhao, F Asta, V Tucci, T Catelani, R Marotta, H Xu, ...
Molecular neurodegeneration 11, 1-20, 2016
1142016
Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells
L Gasparini, M Racchi, L Benussi, D Curti, G Binetti, A Bianchetti, ...
Neuroscience letters 231 (2), 113-117, 1997
1091997
Attenuation of chronic neuroinflammation by a nitric oxide‐releasing derivative of the antioxidant ferulic acid
GL Wenk, K McGann‐Gramling, B Hauss‐Wegrzyniak, D Ronchetti, ...
Journal of neurochemistry 89 (2), 484-493, 2004
992004
Early behavioural markers of disease in P301S tau transgenic mice
ML Scattoni, L Gasparini, E Alleva, M Goedert, G Calamandrei, ...
Behavioural brain research 208 (1), 250-257, 2010
972010
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface
JY Leem, CA Saura, C Pietrzik, J Christianson, C Wanamaker, LST King, ...
Neurobiology of disease 11 (1), 64-82, 2002
972002
Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
L Gasparini, E Ongini, D Wilcock, D Morgan
Brain research reviews 48 (2), 400-408, 2005
962005
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Artigos 1–20