Taisuke Tomita
Taisuke Tomita
Professor at Graduate School of Pharmaceutical Sciences, The University of Tokyo
Email confirmado em mol.f.u-tokyo.ac.jp - Página inicial
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APP processing and synaptic function
F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ...
Neuron 37 (6), 925-937, 2003
17622003
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
M Baba, S Nakajo, PH Tu, T Tomita, K Nakaya, VM Lee, JQ Trojanowski, ...
The American journal of pathology 152 (4), 879, 1998
17051998
AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
H Hsieh, J Boehm, C Sato, T Iwatsubo, T Tomita, S Sisodia, R Malinow
Neuron 52 (5), 831-843, 2006
11142006
The role of presenilin cofactors in the γ-secretase complex
N Takasugi, T Tomita, I Hayashi, M Tsuruoka, M Niimura, Y Takahashi, ...
Nature 422 (6930), 438-441, 2003
10312003
High performance plasma amyloid-β biomarkers for Alzheimer’s disease
A Nakamura, N Kaneko, VL Villemagne, T Kato, J Doecke, V Doré, ...
Nature 554 (7691), 249-254, 2018
6482018
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
P Tu, JE Galvin, M Baba, B Giasson, T Tomita, S Leight, S Nakajo, ...
Annals of neurology 44 (3), 415-422, 1998
6331998
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
T Tomita, K Maruyama, TC Saido, H Kume, K Shinozaki, S Tokuhiro, ...
Proceedings of the National Academy of Sciences 94 (5), 2025-2030, 1997
4771997
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating
KH Cheung, D Shineman, M Müller, C Cardenas, L Mei, J Yang, T Tomita, ...
Neuron 58 (6), 871-883, 2008
4532008
Effects of PS1 deficiency on membrane protein trafficking in neurons
S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ...
Neuron 21 (5), 1213-1221, 1998
4491998
A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and Notch signaling
H Steiner, K Duff, A Capell, H Romig, MG Grim, S Lincoln, J Hardy, X Yu, ...
Journal of Biological Chemistry 274 (40), 28669-28673, 1999
3751999
Neprilysin degrades both amyloid β peptides 1–40 and 1–42 most rapidly and efficiently among thiorphan-and phosphoramidon-sensitive endopeptidases
K Shirotani, S Tsubuki, N Iwata, Y Takaki, W Harigaya, K Maruyama, ...
Journal of Biological Chemistry 276 (24), 21895-21901, 2001
3182001
Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1
M Okochi, H Steiner, A Fukumori, H Tanii, T Tomita, T Tanaka, T Iwatsubo, ...
The EMBO journal 21 (20), 5408-5416, 2002
3072002
A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis
EH Schroeter, MXG Ilagan, AL Brunkan, S Hecimovic, Y Li, M Xu, ...
Proceedings of the National Academy of Sciences 100 (22), 13075-13080, 2003
2562003
Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation
Y Takahashi, I Hayashi, Y Tominari, K Rikimaru, Y Morohashi, T Kan, ...
Journal of Biological Chemistry 278 (20), 18664-18670, 2003
2482003
C-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl …
Y Morohashi, T Kan, Y Tominari, H Fuwa, Y Okamura, N Watanabe, ...
Journal of Biological Chemistry 281 (21), 14670-14676, 2006
2212006
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease
M Takahashi, S Doré, CD Ferris, T Tomita, A Sawa, H Wolosker, ...
Neuron 28 (2), 461-473, 2000
2012000
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
N Takasugi, T Sasaki, K Suzuki, S Osawa, H Isshiki, Y Hori, N Shimada, ...
Journal of Neuroscience 31 (18), 6850-6857, 2011
1832011
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4
Y Morohashi, N Hatano, S Ohya, R Takikawa, T Watabiki, N Takasugi, ...
Journal of Biological Chemistry 277 (17), 14965-14975, 2002
1772002
Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44
D Murakami, I Okamoto, O Nagano, Y Kawano, T Tomita, T Iwatsubo, ...
Oncogene 22 (10), 1511-1516, 2003
1742003
Activity-dependent proteolytic cleavage of neuroligin-1
K Suzuki, Y Hayashi, S Nakahara, H Kumazaki, J Prox, K Horiuchi, ...
Neuron 76 (2), 410-422, 2012
1682012
O sistema não pode efectuar a operação agora. Tente novamente mais tarde.
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